Unsere Signaling Pathways in der Übersicht

ACE Inhibitor Pathway

Das Angiotensin Converting Enzym, ACE genannt, ist die Hauptkomponente des Renin-Angiotensin Systems (RAS). RAS kontrolliert den Blutdruck durch Regelung des Wasser-Elektrolyt-Haushaltes. ACE-Inhibitoren werden zur Behandlung von Herzinsuffizienz und arterieller Hypertonie eingesetzt...

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Apoptose

Apoptose ist ein hochregulierter Prozess, mithilfe dessen sich Organismen auf organisiertem Weg nicht mehr benötigter Zellen entledigen können. Sie wird entweder durch eine bestimmte Klasse von Todesrezeptoren oder durch intrinsische Faktoren wie DNA-Schäden ausgelöst. Die Apoptose wird hauptsächlich von Caspasen angetrieben und weiterhin durch Bcl-2 und Inhibitorproteine reguliert. Eine Dysregulation dieses programmierten Zelltods wird oft mit Krebs in Verbindung gebracht.

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Autophagie

Als Autophagie oder auch Autophagozytose wird gezielte der Abbau und die Verwertung von zelleigenen Bestandteilen bezeichnet. Hierbei werden sowohl kleine fehlgefaltete Proteine als auch ganze Organellen verwertet. Der lysosomale Signalweg initiiert das Umschließen, Abbau und Recycling der zellulären Komponenten, inklusive alternder Proteine und Organellen, und fördert so das Überleben der Zelle.

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DNA Reparatur

In jedem Organismus gewährleisten zahlreiche DNA-Reparaturmechanismen die Integrität der im Kern einer jeden Zelle enthaltenen genetischen Information. Die zentrale Bedeutung der DNA-Integrität wird anhand der zahlreichen unterschiedlichen Signalwege für die DNA-Reparatur sowie den verschiedenen an diesen Prozessen beteiligten Proteinen deutlich.

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Hedgehog Signalweg

Der Hedgehog-Signalweg ist einer der maßgeblichsten Bestimmungsfaktoren für viele Entwicklungsprozesse. Die Genprodukte der Zielgene legen die Zellabstammung, -erneuerung, das Zellüberleben und die Zellmigration fest. Eine Deregulierung der Hedgehog-Signalwegproteine und nachgelagerte Effektoren spielen eine zentrale Rolle bei der Tumorentwicklung.

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JAK-STAT Signalweg

Die JAK-STAT-Signalübertragung ist bei Wirbeltieren und auch einigen anderen Vielzellern evolutionär konserviert. Die Kombination aus rezeptoraktivierten Kinasen und...

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Komplementsystem

Das Komplementsystem ist Teil des angeborenen Immunsystems und spielt eine wichtige Rolle bei Abwehrmechanismen, Entzündungen, der Geweberegeneration und anderen physiologischen Prozessen. Die Komplementaktivierung führt zur...

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MAPK Signalweg

Phosphorylierung ist das reversible Anhängen einer Phosphatgruppe an einen spezifischen Aminosäurerest eines Moleküls. Auf funktionaler Ebene dient die Phosphorylierung als einfacher molekularer Schalter, der die Funktion eines Proteins aktivieren, deaktivieren oder anpassen kann. Das Anhängen und die Entfernung von Phosphatgruppen gewährleistet die räumliche und zeitliche Kontrolle über die Proteinaktivität.

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Microtubule Dynamics

Mikrotubuli sind hochdynamische strukturelle und funktionelle intrazelluläre „Autobahnen”. Der Begriff Zytoskelett (Cytoskelett) ruft das Bild einer starren, unveränderlichen und permanenten Struktur hervor. In Wirklichkeit ist das Zytoskelett allerdings ein hochdynamisches miteinander verbundenes Netzwerk, das aus drei unterschiedlichen Hauptkomponenten besteht: Mikrotubuli...

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NF-kappaB Signalweg

NF-kappaB (nuclear factor k-light-chain-enhancer of activated B cells) ist eine Gruppe homo- und heterodimerischer Transkriptionsfaktoren, die zentraler Bestandteil eines Netzwerks unterschiedlicher Signaltransduktionswege sind. Eine Vielzahl von...

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Notch Signalweg

Der hoch konservierte Notch-Signalweg ist einzigartig, da es sich beim Notch-Rezeptor und einem Großteil seiner Liganden (Mitglieder der DSL(Delta/Serrate/Lag-2)-Familie) um Transmembranproteine handelt,...

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p53 Signalweg

p53 ist einer der am häufigsten in der Forschung vertretenen Tumor Supressoren und wird oft als "der Wächter des Genoms" bezeichnet. Mutationen von p53 oder von Elementen innerhalb seiner regulatorischen Kreisläufe sind bei nahezu allen Krebsarten zu finden. Aus diesem Grunde kommt p53 eine besondere Signifikanz zu. p53 erhält die Stabilität...

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PI3K-Akt Signalweg

Der PI3K/AKT-Signalweg ist ein ausschlaggebender Faktor bei der zellulären Homöostase, der neurologischen Entwicklung, beim Stoffwechsel und anderen Prozessen. Er reguliert zahlreiche Abschnitte der Zellentwicklung wie die Apoptose, die Zellzyklusprogression und die Zelldifferenzierung. Der Hauptregulator des PI3K/AKT-Signalwegs ist AKT/PKB, eine Familie dreier eng verwandter Serin/Threonin-Kinasen...

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RTK Signalweg

Rezeptor Tyrosin Kinasen (RTKs) sind membrangebundene Kinasen, die nach der Bindung rezeptorspezifischer Liganden aktiviert werden. Sie stellen die größte Klasse der Membranrezeptoren dar, die Signalkaskaden durch ihre charakteristische Enzymaktivität auslösen.

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T-Zell Rezeptor Signalweg

Der T-Zell Rezeptor (TCR) ist ein Proteinkomplex auf der Oberfläche von T-Zellen und dient der Erkennung von Antigenen. Durch Aktivierung wird eine Signalkaskade in Gang gesetzt die in der T-Zelle Differenzierung, Vermehrung und Ausschüttung von Cytokinen induziert.

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TLR Signalweg

Toll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.

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WNT Signalweg

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...

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Zellzyklus

Cell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.

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Activated T Cell Proliferation

Browse our antibodies, ELISA kits and proteins related to activated T cell proliferation.

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Activation of Innate immune Response

Browse our antibodies, ELISA kits and proteins related to the activation of innate immune response.

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AMPK Signaling

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Asymmetric Protein Localization

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Brown Fat Cell Differentiation

Browse our antibodies, ELISA kits and proteins related to brown fat cell differentiation.

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C21-Steroid Hormone Metabolic Process

Browse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.

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cAMP Metabolic Process

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Carbohydrate Homeostasis

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Caspase Kaskade in der Apoptose

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Cell RedoxHomeostasis

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Cell-Cell Junction Organization

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Cellular Glucan Metabolic Process

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Cellular Response to Molecule of Bacterial Origin

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Chromatin Binding

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CXCR4-mediated Signaling Events

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Dicarboxylic Acid Transport

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DNA Replication

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Dopaminergic Neurogenesis

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EGFR Downregulation

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EGFR Signaling Pathway

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Embryonic Body Morphogenesis

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ER-Nucleus Signaling

Browse our antibodies, ELISA kits and proteins related to the ER-nucleus signaling pathway.

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Fc-epsilon Rezeptor Signalübertragung

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Feeding Behaviour

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G-protein mediated Events

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Glycosaminoglycan Metabolic Process

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Growth Factor Binding

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Hepatitis C

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Hormone Activity

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Hormone Transport

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Inositol Metabolic Process

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Integrin Complex

Browse our antibodies, ELISA kits and proteins related to the integrin complex.

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Interaction of EGFR with phospholipase C-gamma

Browse our antibodies, ELISA kits and proteins related EGFR and its interaction with phospholipase C-gamma.

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Interferon-gamma Pathway

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Intracellular Steroid Hormone Receptor Signaling Pathway

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M Phase

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Maintenance of Protein Location

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Metabolism of Steroid Hormones and Vitamin D

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Methionine Biosynthetic Process

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Mitotic G1-G1/S Phases

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Monocarboxylic Acid Catabolic Process

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Myometrial Relaxation and Contraction

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Negative Regulation of Hormone Secretion

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Negative Regulation of intrinsic apoptotic Signaling

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Negative Regulation of Transporter Activity

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Neurotrophin Signalübertragung

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

Durchsuchen Sie unsere Antikörper, ELISA Kits und Proteine zu Targets aus der Nucleotide Phosphorylation.

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Peptide Hormone Metabolism

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Photoperiodism

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Phototransduction

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Platelet-derived growth Factor Receptor Signaling

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Positive Regulation of Endopeptidase Activity

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Positive Regulation of fat Cell Differentiation

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Positive Regulation of Immune Effector Process

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Positive Regulation of Peptide Hormone Secretion

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Positive Regulation of Response to DNA Damage Stimulus

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Production of Molecular Mediator of Immune Response

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Protein targeting to Nucleus

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Proton Transport

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Regulation of Actin Filament Polymerization

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Regulation of Carbohydrate Metabolic Process

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Regulation of Cell Size

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Regulation of G-Protein Coupled Receptor Protein Signaling

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Regulation of Hormone Biosynthetic Process

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

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Regulation of Leukocyte Mediated Immunity

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Regulation of Lipid Metabolism by PPARalpha

Browse our antibodies, ELISA kits and proteins related to the Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

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Regulation of long-term Neuronal Synaptic Plasticity

Browse our antibodies, ELISA kits and proteins related to regulation of long-term neuronal synaptic plasticity.

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Regulation of Muscle Cell Differentiation

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Regulation of Systemic Arterial Blood Pressure by Hormones

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Regulatorische RNA Pathways

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Response to Growth Hormone Stimulus

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Response to Water Deprivation

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Retinoic Acid Receptor Signaling Pathway

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Ribonucleoprotein Complex Subunit Organization

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Ribonucleoside Biosynthetic Process

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Ribosome Assembly

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Sensory Perception of Sound

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Signaling Events mediated by VEGFR1 and VEGFR2

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Signaling of Hepatocyte Growth Factor Receptor

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Skeletal Muscle Fiber Development

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Smooth Muscle Cell Migration

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Stem Cell Maintenance

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Steroid Hormone Biosynthesis

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Steroid Hormone Mediated Signaling Pathway

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Synaptic Membrane

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Synaptic Vesicle Exocytosis

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Synthesis of DNA

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Telomere Maintenance

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Thromboxane A2 Receptor Signaling

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Thyroid Hormone Synthesis

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Toll-Like Receptors Cascades

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Transition Metal Ion Homeostasis

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Tube Formation

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VEGFR1 Specific Signals

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