NFAT1 Antikörper (AA 594-676)

Produktnummer ABIN5519044

Produktdetails anti-NFAT1 Antikörper

Target: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Bindungsspezifität: AA 594-676

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFAT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Rabbit IgG polyclonal antibody for NFAT1 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for NFAT1 detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
Gene Name: nuclear factor of activated T-cells 2
Protein Name: Nuclear factor of activated T-cells, cytoplasmic 2

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived huamn NFAT1 recombinant protein (Position: Q594-H676).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-NFAT1 Antikörper (ABIN5519044)

Bai, Li, Wang, Lian, Wang: "The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB." in: International journal of molecular medicine, Vol. 40, Issue 1, pp. 155-163, (2018) (PubMed).

Details zu NFAT1

Target: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Andere Bezeichnung: NFATC2 (NFAT1 Produkte)

Synonyme: NFATC2 antikoerper, AI607462 antikoerper, NF-ATc2 antikoerper, NFAT1 antikoerper, NFAT1-D antikoerper, Nfatp antikoerper, NFATP antikoerper, nuclear factor of activated T-cells 2 antikoerper, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 antikoerper, NFATC2 antikoerper, nfatc2 antikoerper, Nfatc2 antikoerper

Hintergrund: NFATC2(Nuclear factor of activated T-cells, cytoplasmic 2), also known as NFATP or the 'preexisting component' of NFAT, is present in the cytosolic fraction of unstimulated T cells, which is also a member of the nuclear factor of activated T cells (NFAT) family. The NFATC2 gene is mapped on 20q13.2. NFATC2 is highly homologous to NFATC1 over a limited domain which shows similarity to the Dorsal/Rel family but has a wider tissue distribution. Ectopic expression of NFATC2 inhibited the basal activity of the human CDK4 promoter. Additionally, both Calna-/- and Nfatc2 -/- mice had elevated protein levels of Cdk4, confirming a negative regulatory role for the calcineurin/NFAT pathway. NFATC2 controls myoblast fusion at a specific stage of myogenesis after the initial formation of a myotube and is necessary for further cell growth. Overexpression of NFATC2 promoted differentiation of osteoclast precursor cells into tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated osteoclast-like cells even in the absence of RANKL.

Synonyms: Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1, NFATC2, NFAT1, NFATP

Gen-ID: 4773

UniProt: Q13469

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, VEGF Signaling, BCR Signaling