NFAT1 Antikörper (C-Term)

Produktnummer ABIN2780879

Produktdetails anti-NFAT1 Antikörper

Target: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFAT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PTVIQQQNAT SQRAAKNGPP VSDQKEVLPA GVTIKQEQNL DQTYLDDVNE

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against NFATC2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NFATC2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 925 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NFAT1

Target: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Andere Bezeichnung: NFATC2 (NFAT1 Produkte)

Synonyme: NFATC2 antikoerper, AI607462 antikoerper, NF-ATc2 antikoerper, NFAT1 antikoerper, NFAT1-D antikoerper, Nfatp antikoerper, NFATP antikoerper, nuclear factor of activated T-cells 2 antikoerper, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 antikoerper, NFATC2 antikoerper, nfatc2 antikoerper, Nfatc2 antikoerper

Hintergrund: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: NFAT1, NFATP
Protein Interaction Partner: GNB2, USP22, UBC, TNPO1, CSE1L, LRRK2, IQGAP1, PPP2R1A, JUN, NFATC2, CREBBP, IRF2BP2, TFAP4, HNRNPA1, TAF9, TUBA1A, KPNB1, SUV39H1, MAPK9, MAPK8, MED31, NFATC2IP, EP300, IRF4, PPP3R1, YWHAZ, PIN1, MEF2D, FOXP3, VIM, PRKCZ, YWHAQ, EGR4, EGR1, PPP3CB,
Protein Size: 925

Molekulargewicht: 100 kDa

Gen-ID: 4773

NCBI Accession: NM_173091, NP_775114

UniProt: Q13469

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, VEGF Signaling, BCR Signaling