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Ion Channels

Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles. Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP3 receptors) are relatively voltage-insensitive and are gated by second messengers and other intracellular and/or extracellular mediators.(1)

Most ion channels are highly selective for the class of ions crossing the channel. They can therefore be easily classified into sodium channels, calcium channels, potassium channels, proton channels or non-selective cation channels. Research on ion channels requires a large number of methods and materials. We offer monoclonal and polyclonal antibodies, ELISA kits and high-quality made-to-order proteins for this complex topic.

Aquaporins

Aquaporins (often called aquaporin water channels) are a family of small, integral membrane proteins that are expressed broadly throughout the animal and plant kingdoms. They have a similar basic structure, with aquaporin monomers consisting of six transmembrane helical segments and two short helical segments that surround cytoplasmic and extracellular vestibules connected by a narrow aqueous pore.(2)

To search our Aquaporin antibodies, kits, proteins click on the links below.

Calcium Channels

A calcium channel is a transmembrane ion channel that is permeable to calcium ions. The permeability is controlled either by voltage-gated calcium channels or ligand-gated calcium channels. We offer some hand-picked monoclonal and polyclonal antibodies for research on calcium channels.

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, IF, IP, IHC, WB
Kat. Nr.ABIN1721482
Menge100 μg
ReaktivitätHuman, Mouse, Rabbit, Rat
KlonalitätMonoclonal
ApplikationICC, FACS, IF, IP, IHC, WB
Kat. Nr.ABIN1721483
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationIHC, WB
Kat. Nr.ABIN1098196
Menge100 μg
ReaktivitätRat
KlonalitätMonoclonal
ApplikationFM, IHC, IP, WB
Kat. Nr.ABIN6658066
Menge100 μg
ReaktivitätMammalian
KlonalitätMonoclonal
ApplikationISt, IHC, WB
Kat. Nr.ABIN1304586
Menge5 mL
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, IF, IHC, WB
Kat. Nr.ABIN1721488
Menge100 μg
ReaktivitätHuman, Mouse
KlonalitätPolyclonal
ApplikationICC, IF, IHC (p), WB
Kat. Nr.ABIN2854649
Menge100 μL
ReaktivitätMammalian
KlonalitätMonoclonal
ApplikationISt, IHC, WB
Kat. Nr.ABIN1304590
Menge5 mL

See all Calcium Channel Antibodies

Potassium Channels

Potassium channels ubiquitously exist in nearly all kingdoms of life and perform diverse but important functions. Since the first atomic structure of a prokaryotic potassium channel (KcsA, a channel from Streptomyces lividans) was determined, tremendous progress has been made in understanding the mechanism of potassium channels and channels conducting other ions.(3)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätMouse
KlonalitätMonoclonal
ApplikationIHC, IP, WB
Kat. Nr.ABIN6657685
Menge100 μg
ReaktivitätMouse
KlonalitätMonoclonal
ApplikationFM, IHC, IP, WB
Kat. Nr.ABIN6657686
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, FACS, IF, IP, IHC, WB
Kat. Nr.ABIN1721589
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, FACS, IF, IP, IHC, WB
Kat. Nr.ABIN1721590
Menge100 μg
ReaktivitätCow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN2776142
Menge100 μL
ReaktivitätHuman
KlonalitätMonoclonal
ApplikationFACS, ELISA, WB
Kat. Nr.ABIN969227
Menge100 μL
ReaktivitätHamster, Human, Mouse, Rat
KlonalitätMonoclonal
ApplikationAA, ICC, IF, IHC, IP, WB
Kat. Nr.ABIN2482775
Menge100 μg
ReaktivitätHuman, Mouse, Pig, Rat
KlonalitätPolyclonal
ApplikationELISA
Kat. Nr.ABIN570733
Menge100 μg
ReaktivitätHuman, Mouse
KlonalitätPolyclonal
ApplikationELISA, WB
Kat. Nr.ABIN3185286
Menge100 μL

Sodium Channels

There are two major classes of sodium channels in mammals: The voltage-gated sodium channel (VGSC) family and the epithelial sodium channel (ESC). Voltage-gated sodium channels exist throughout the body in various cell types, while epithelial sodium channels are located primarily in the skin and kidney.(4)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN2776229
Menge100 μL
ReaktivitätHamster, Human, Mouse, Rat, Xenopus laevis
KlonalitätPolyclonal
ApplikationICC, IF, IHC, WB
Kat. Nr.ABIN863204
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätPolyclonal
ApplikationIF (p), IHC (p), WB
Kat. Nr.ABIN713471
Menge100 μL
ReaktivitätHamster, Human, Mouse, Rat, Xenopus laevis
KlonalitätPolyclonal
ApplikationICC, IF, IHC, WB
Kat. Nr.ABIN2486428
Menge100 μg
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationELISA, WB
Kat. Nr.ABIN565642
Menge50 μL
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, IF, WB
Kat. Nr.ABIN2483030
Menge100 μg

TRP

Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.(5)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman, Mouse, Rat
KlonalitätPolyclonal
ApplikationIHC, WB
Kat. Nr.ABIN351117
Menge100 μL
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationAA, IHC, IP, WB
Kat. Nr.ABIN2485379
Menge100 μg
ReaktivitätHuman, Chimpanzee
KlonalitätMonoclonal
ApplikationIHC, ELISA, WB
Kat. Nr.ABIN964697
Menge100 μg
ReaktivitätDog, Human, Monkey
KlonalitätMonoclonal
ApplikationIHC, WB
Kat. Nr.ABIN2725815
Menge0.1 mL
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationEIA, IHC (p), WB
Kat. Nr.ABIN4620541
Menge0.1 mg

See all TRP-related Antibodies

Cyclic Nucleotide-gated Ion Channels

Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). They are opened by the direct binding of cyclic nucleotides, cAMP and cGMP. Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels.(6) Below you will find a selection of polyclonal antibodies against CNG ion channels.

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationICC, IF, IHC (p), WB
Kat. Nr.ABIN2856869
Menge100 μL
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN1679299
Menge100 μg
ReaktivitätMouse
KlonalitätPolyclonal
ApplikationIHC (p), WB
Kat. Nr.ABIN5532896
Menge400 μL
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN5619308
Menge100 μL

See all CNG ion channel Antibodies

Hyperpolarization-activated Cyclic Nucleotide-gated Channels (HCN)

A hyperpolarization-activated cyclic nucleotide-gated channel (HCN) is a subtype of CNG channel that is gated by hyperpolarization of the cell membrane. There are four HCN channels HCN1, HCN2, HCN3, and HCN4.

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationAA, IHC, IP, WB
Kat. Nr.ABIN2483966
Menge100 μg
ReaktivitätRat
KlonalitätMonoclonal
ApplikationFM, IHC, IP, WB
Kat. Nr.ABIN6658118
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationAA, ICC, IF, IHC, WB
Kat. Nr.ABIN2483847
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätPolyclonal
ApplikationIF (p), IHC (p), WB
Kat. Nr.ABIN733043
Menge100 μL

See all HCN ion channel Antibodies

We offer you Made-to-order Channel Proteins

We offer high-purity made-to-order ion channel proteins with native state folding guarantee. Below you will find a selection of potassium channel proteins. Please contact us via email, chat, or phone for more information about our made-to-order proteins.

Produkt
Protein Type
Conjugate
Kat. Nr.
Menge
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3077909
Menge1 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3081371
Menge1 mg
Protein TypeRecombinant
Conjugaterho-1D4 tag
Kat. Nr.ABIN3093343
Menge0.5 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3130433
Menge1 mg

References:

  • (1) Ion Channels. Br J Pharmacol. 2011 Nov;164(Suppl 1):S137–S174. doi: 10.1111/j.1476-5381.2011.01649_5.x. PMCID: PMC3315630.
  • (2) Verkman AS. Aquaporins. Curr Biol. 2013 Jan 21;23(2):R52-5. doi: 10.1016/j.cub.2012.11.025. PMID: 23347934; PMCID: PMC3590904.
  • (3) Kuang Q, Purhonen P, Hebert H. Structure of potassium channels. Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13. PMID: 26070303; PMCID: PMC4565861.
  • (4) Hernandez CM, Richards JR. Physiology, Sodium Channels. [Updated 2019 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545257/
  • (5) Dhakal S, Lee Y. Transient Receptor Potential Channels and Metabolism. Mol Cells. 2019 Aug 31;42(8):569-578. doi: 10.14348/molcells.2019.0007. PMID: 31446746; PMCID: PMC6715338.
  • (6) Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels. Physiol Rev. 2002 Jul;82(3):769-824.
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