KCNK3 Antikörper (C-Term)

Produktnummer ABIN2776142

Produktdetails anti-KCNK3 Antikörper

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Bindungsspezifität: C-Term

Reaktivität: Ratte, Maus, Human, Hund, Rind (Kuh), Meerschweinchen, Schaf, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TCVEQSHSSP GGGGRYSDTP SRRCLCSGAP RSAISSVSTG LHSLSTFRGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KCNK3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 394 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KCNK3 Antikörper (ABIN2776142)

Donner, Schullenberg, Geduldig, Hüning, Mersmann, Zacharowski, Kovacevic, Decking, Aller, Schmidt: "Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability." in: Basic research in cardiology, Vol. 106, Issue 1, pp. 75-87, (2010) (PubMed).

Nogueira, Gerry, Mantero, Mariniello, Rainey: "The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas." in: Clinical endocrinology, Vol. 73, Issue 1, pp. 22-9, (2010) (PubMed).

Details zu KCNK3

Target: KCNK3 (Potassium Channel, Subfamily K, Member 3 (KCNK3))

Andere Bezeichnung: KCNK3 (KCNK3 Produkte)

Synonyme: si:dkey-164m15.1 antikoerper, K2p3.1 antikoerper, OAT1 antikoerper, PPH4 antikoerper, TASK antikoerper, TASK-1 antikoerper, TBAK1 antikoerper, cTBAK-1 antikoerper, Task-1 antikoerper, rTASK antikoerper, KCNK3 antikoerper, potassium channel, subfamily K, member 3a antikoerper, potassium two pore domain channel subfamily K member 3 antikoerper, potassium channel, subfamily K, member 3 antikoerper, kcnk3a antikoerper, KCNK3 antikoerper, Kcnk3 antikoerper

Hintergrund: KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
Alias Symbols: TASK, TBAK1, K2p3.1, TASK-1
Protein Interaction Partner: YWHAB, COPB1, YWHAG, YWHAE, SFN, YWHAZ, YWHAQ, S100A10, YWHAH,
Protein Size: 394

Molekulargewicht: 43 kDa

Gen-ID: 3777

NCBI Accession: NM_002246, NP_002237

UniProt: O14649