Nav1.8 Antikörper (AA 1724-1956)
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- Target Alle Nav1.8 (SCN10A) Antikörper anzeigen
- Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
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Bindungsspezifität
- AA 1724-1956
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Nav1.8 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)
- Spezifität
- Detects ~220 kDa. No cross reactivity against other Nav channels.
- Kreuzreaktivität
- Human, Affe, Maus, Ratte
- Aufreinigung
- Protein G Purified
- Immunogen
- Fusion protein amino acids 1724-1956 of rat Nav1.8
- Klon
- S134
- Isotyp
- IgG2a
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- Applikationshinweise
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- WB (1:1000)
- IHC (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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1 μg/ml of ABIN863135 was sufficient for detection of Nav1.8 in 10 μg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- -20°C
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Effects of HIV-1 Tat on enteric neuropathogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, (2014) (PubMed).
: "
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Effects of HIV-1 Tat on enteric neuropathogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, (2014) (PubMed).
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- Target
- Nav1.8 (SCN10A) (Sodium Channel, Voltage-Gated, Type X, alpha Subunit (SCN10A))
- Andere Bezeichnung
- Nav1.8 (SCN10A Produkte)
- Synonyme
- Nav1.8 antikoerper, PN3 antikoerper, SNS antikoerper, hPN3 antikoerper, Na(V)1.8 antikoerper, sodium channel, voltage-gated, type X, alpha antikoerper, sodium voltage-gated channel alpha subunit 10 antikoerper, Scn10a antikoerper, SCN10A antikoerper
- Hintergrund
- Nav1.8 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.8 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.8 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
- Gen-ID
- 29571
- NCBI Accession
- NP_058943
- UniProt
- Q62968
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