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Fc Receptor (FcRn) Antikörper Primary Antibody

Reaktivität: Human cELISA, FACS, ELISA Wirt: Maus Monoclonal ADM31 unconjugated
Pubmed (1)
Produktnummer ABIN1774762
$495.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 bis 7 Werktagen
  • Target
    Fc Receptor (FcRn)
    Reaktivität
    • 1
    • 1
    Human
    Wirt
    • 1
    Maus
    Klonalität
    • 1
    Monoklonal
    Applikation
    Cell-ELISA (cELISA), Flow Cytometry (FACS), ELISA
    Produktmerkmale
    based on recognition of the complete native protein expressed on transfected mammalian cells
    Aufreinigung
    Purified, Protein A
    Immunogen
    Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.
    Klon
    ADM31
    Isotyp
    IgG2b
  • Applikationshinweise
    • Flow cytometry: 1.2 μg/10^6 cells
    • ELISA: 1:200 - 1:400
    • CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    phosphate buffered saline, pH 7.2
    Handhabung
    avoid repeated freezing and thawing
    Lagerung
    4 °C
  • Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, 2014 (PubMed).

  • Target
    Fc Receptor (FcRn)
    Hintergrund
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
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