IKBKG Antikörper

Produktnummer ABIN6655353

Produktdetails anti-IKBKG Antikörper

Target: IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IKBKG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: Anti-IKKg Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IKKg from Human based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-IKKg from other sources has not been determined.

Immunogen:

Immunogen: IKK gamma Antibody was produced in mice prepared by repeated immunizations with human IKKgamma (NEMO) protein at full-length.

Immunogen Type: Native Protein

Klon: 46B844

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Application Note: Anti-IKKgamma antibody is suitable for use in Flow (I) and WB. Expect a band approximately 48 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Flow Cytometry Dilution: 0.1-0.5/10^6 cells

Western Blot Dilution: 2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu IKBKG

Target: IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))

Andere Bezeichnung: IKK gamma (IKBKG Produkte)

Synonyme: AMCBX1 antikoerper, FIP-3 antikoerper, FIP3 antikoerper, Fip3p antikoerper, IKK-gamma antikoerper, IP antikoerper, IP1 antikoerper, IP2 antikoerper, IPD2 antikoerper, NEMO antikoerper, ZC2HC9 antikoerper, 1110037D23Rik antikoerper, AI848108 antikoerper, AI851264 antikoerper, AW124339 antikoerper, IKK[g] antikoerper, Nemo antikoerper, nemo antikoerper, fj33c07 antikoerper, wu:fj33c07 antikoerper, zgc:113492 antikoerper, MGC97885 antikoerper, IKBKG antikoerper, IKBKG_1 antikoerper, IKBKG_2 antikoerper, CG16910 antikoerper, DmIKK-gamma antikoerper, DmIKKgamma antikoerper, Dmel\\CG16910 antikoerper, Dmikkgamma antikoerper, IKK antikoerper, IKK[[gamma]] antikoerper, IKKg antikoerper, IKKgamma antikoerper, KEY antikoerper, Kenny antikoerper, Key antikoerper, dIKK antikoerper, dIKK-gamma antikoerper, dmIKKgamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma antikoerper, inhibitor of kappaB kinase gamma antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog antikoerper, kenny antikoerper, IKBKG antikoerper, Ikbkg antikoerper, ikbkg antikoerper, ikbkg.L antikoerper, IKBKG_1 antikoerper, key antikoerper

Hintergrund:

Synonyms: FIP3, NEMO, NF-kappa-B essential modulator, NEMO, FIP-3, IkB kinase-associated protein 1, IKKAP1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, I-kappa-B kinase subunit gamma, IKK-gamma, IKKG, IkB kinase subunit gamma, NF-kappa-B essential modifier

Background: Anti-IKK gamma detects human IKKgamma. NF-kappaB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kappaB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKKalpha, IKKbeta, and IKKgamma (NEMO). NEMO (NF-kB Essential MOdulator) preferentially interacts with IKK2/b and is required for activation of IKK complex. Recent data suggest that the human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKKalpha nor IKKbeta, but complexes directly with NEMO. This suggests that NEMO may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb. Anti-IKKgamma antibody is ideal for investigators involved in NFkappaB, kinase and growth factor research.

Gene Name: IKBKG

Gen-ID: 8517

NCBI Accession: NP_001093326

UniProt: Q9Y6K9

Pathways: NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine