NFKB1 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2727210

Produktdetails

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NFKB1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human NF-kB p105 / p50 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Andere Bezeichnung: Nf-Kb p105,p50 (NFKB1 Produkte)

Synonyme: GKLP Protein, NKTL Protein, NTKL Protein, P105 Protein, TAPK Protein, TEIF Protein, TRAP Protein, EBP-1 Protein, KBF1 Protein, NF-kB1 Protein, NF-kappa-B Protein, NF-kappaB Protein, NFKB-p105 Protein, NFKB-p50 Protein, NFkappaB Protein, p105 Protein, p50 Protein, NF-kB Protein, NF-KB1 Protein, ebp-1 Protein, kbf1 Protein, nf-kappa-b Protein, nf-kappaB Protein, nfkb-p105 Protein, nfkb-p50 Protein, NF-kappaB1 Protein, p50/p105 Protein, BICDR-1 Protein, bicdr1 Protein, ccdc64 Protein, SCY1 like pseudokinase 1 Protein, nuclear factor kappa B subunit 1 Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog Protein, nuclear factor NF-kappa-B p105 subunit Protein, nucleoporin 107 Protein, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Protein, SCYL1 Protein, NFKB1 Protein, Nfkb1 Protein, nfkb1.L Protein, CpipJ_CPIJ012236 Protein, Nup107 Protein, nfkb1 Protein

Hintergrund: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

Molekulargewicht: 105.2 kDa

NCBI Accession: NP_003989

Pathways: p53 Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteine