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anti-Mouse (Murine) PARD3 Antikörper:
anti-Rat (Rattus) PARD3 Antikörper:
anti-Human PARD3 Antikörper:
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Human Polyclonal PARD3 Primary Antibody für ICC, IF - ABIN4343686
Whiteman, Fan, Harder, Walton, Liu, Soofi, Fogg, Hershenson, Dressler, Deutsch, Gumucio, Margolis: Crumbs3 is essential for proper epithelial development and viability. in Molecular and cellular biology 2013
Show all 3 Pubmed References
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.
HTT (zeige HTT Antikörper) is required for the apical localization of PAR3 (zeige F2RL2 Antikörper)-aPKC during epithelial morphogenesis in virgin, pregnant, and lactating mice.
Authors identify the cell polarity protein Par3, a negative regulator of neuronal differentiation, as a Smek1 (zeige SMEK1 Antikörper) substrate and demonstrate that Smek1 (zeige SMEK1 Antikörper) suppresses its activity.
Par3 (zeige F2RL2 Antikörper) (and protein kinase C zeta (zeige PRKCZ Antikörper)) are activated in neurons when binding to N2-proteoglygan.
Suggest that loss of Par3 (zeige F2RL2 Antikörper) promotes metastatic behaviour of ErbB2 (zeige ERBB2 Antikörper)-induced breast tumour epithelial cells by decreasing cell-cell cohesion.
Par3 (zeige F2RL2 Antikörper) is identified as a regulator of signaling pathways relevant to invasive breast cancer.
The nucleus of a myoblast moves rapidly after fusion towards the central myotube nuclei which is driven by microtubules and dynein/dynactin (zeige DCTN1 Antikörper) complex, and requires Cdc42 (zeige CDC42 Antikörper), Par6 (zeige PARD6A Antikörper) and Par3 (zeige F2RL2 Antikörper).
Data suggest that aPKC phosphorylates JAM-A (zeige F11R Antikörper) at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.
Brain-derived neurotrophic factor (BDNF (zeige BDNF Antikörper)) induces polarized signaling of small GTPase (zeige RACGAP1 Antikörper) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3 (zeige F2RL2 Antikörper)) protein.
Report a willin(FRMD6 (zeige FRMD6 Antikörper))/Par3 (zeige F2RL2 Antikörper)-aPKC-ROCK pathway that controls epithelial apical morphology.
PARD3 might play a tumor suppressor role in esophageal squamous cell carcinoma.
Loss of Par3 (zeige F2RL2 Antikörper) promotes metastatic behavior in lung adenocarcinoma cells through 14-3-3zeta (zeige YWHAZ Antikörper) protein.
Studies suggest that rare deleterious variants of PARD3 in the aPKC-binding region contribute to human cranial neural tube defect (NTD).
These data highlight the importance of the carboxy-terminal motif of the E6 protein and downregulation of PAR3 (zeige F2RL2 Antikörper) in tumorigenic transformation of human cervical keratinocytes.
Results suggest that Par3 (zeige F2RL2 Antikörper) expression is likely involved in ovarian cancer progression, especially in peritoneal metastasis, probably through modulating IL-6 (zeige IL6 Antikörper) /STAT3 (zeige STAT3 Antikörper) signaling.
reduced keratinocytes Par3 function fosters a permissive P-cadherin-dependent niche for melanocytes transformation, invasion, and metastasis.
These results demonstrate the importance of Par3 (zeige F2RL2 Antikörper) and SNAIL (zeige SNAI1 Antikörper) in development of KSHV-induced B-cells cancers
PAR-3 (zeige F2RL2 Antikörper) protein expression is frequently lost in primary esophageal squamous cell carcinoma and loss of the PAR-3 (zeige F2RL2 Antikörper) protein is associated with aggressive clinicopathological features.
Taken together, these results suggest that the Par3 (zeige F2RL2 Antikörper) regulates invasion and metastasis in pancreatic cancers by controlling tight junction assembly via Tiam1 (zeige TIAM1 Antikörper).
Knockdown of the polarity protein Par3 reversed the effects of Galpha13 (zeige GNA13 Antikörper) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
Pard3 mediates contact inhibition between neural crest cells and promotes timely myelin gene expression but is not essential for neural crest migration or myelination.
these results demonstrate a novel role of Par3 during neural crest migration, which is likely to be conserved in other processes that involve contact inhibition of locomotion such as cancer invasion or cell dispersion.
Pard3 and Rab11a (zeige RAB11A Antikörper) are necessary for lumen formation in the neural rod.
Brain-derived neurotrophic factor (BDNF (zeige BDNF Antikörper)) induces polarized signaling of small GTPase (zeige RACGAP1 Antikörper) (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Study demonstrates that the microtubule cytoskeleton gradually transitions from a radial to linear organization during neurulation and that microtubules function in conjunction with the polarity protein Pard3 to mediate centrosome positioning.
Agouti signaling (ASIP) genes exist in many species in lower vertebrates and were most probably present in early stages of vertebrate evolution.
Apical localization of ASIP in neuroepithelial cells involves the oligomerization domain CR1 (zeige TDGF1 Antikörper), the PDZ (zeige INADL Antikörper) domains, and the C-terminal portion of the protein.
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins\; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
partitioning-defective protein 3 homolog
, partitioning defective 3 homolog
, par-3 partitioning defective 3 homolog (C. elegans)
, atypical PKC isotype-specific-interacting protein
, ephrin-interacting protein
, atypical PKC-specific binding protein
, atypical PKC-specific-binding protein
, partitioning-defective 3 homolog
, three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)
, CTCL tumor antigen se2-5
, atypical PKC isotype-specific interacting protein
, par-3 family cell polarity regulator alpha
, par-3 partitioning defective 3 homolog