C-JUN Antikörper (pTyr170) (Alexa Fluor 488)

Produktnummer ABIN879107

Produktdetails anti-C-JUN Antikörper (Alexa Fluor 488)

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Bindungsspezifität: pTyr170

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C-JUN Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human c-Jun around the phosphorylation site of Tyr170

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu C-JUN

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Andere Bezeichnung: c-Jun (JUN Produkte)

Synonyme: AP-1 antikoerper, AP1 antikoerper, c-Jun antikoerper, fj36h07 antikoerper, wu:fj36h07 antikoerper, zgc:65863 antikoerper, Junc antikoerper, c-jun antikoerper, CG2275 antikoerper, D-Jun antikoerper, D-jun antikoerper, D-jun/Jra antikoerper, DJUN antikoerper, DJun antikoerper, Djun antikoerper, Dmel\\CG2275 antikoerper, JRA antikoerper, JUN antikoerper, Jun antikoerper, V antikoerper, cJun antikoerper, d-JRA antikoerper, d-Jun antikoerper, d-jun antikoerper, dAP-1 antikoerper, dJRA antikoerper, dJUN antikoerper, dJra antikoerper, dJun antikoerper, djun antikoerper, dm-Jun antikoerper, jra antikoerper, jun antikoerper, l(2)46Ef antikoerper, l(2)IA109 antikoerper, l(2R)IA109 antikoerper, Jun proto-oncogene, AP-1 transcription factor subunit antikoerper, jun proto-oncogene S homeolog antikoerper, jun proto-oncogene antikoerper, Jun-related antigen antikoerper, jun proto-oncogene L homeolog antikoerper, JUN antikoerper, Jun antikoerper, jun.S antikoerper, jun antikoerper, Jra antikoerper, jun.L antikoerper

Hintergrund:

Synonyms: c-Jun phospho Y170, p-c-Jun phospho Y170, c-Jun Tyr170, Jun oncogene, JUN, Activator Protein 1, AP 1, AP1, AP-1, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, JUN protein, JUNC, p39, Proto oncogene cJun, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, vJun Avian Sarcoma Virus 17 Oncogene Homolog, JUN_HUMAN, Transcription factor AP-1, Activator 1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog.

Background: The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Gen-ID: 3725

Pathways: MAPK Signalweg, RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteine