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p53 Antikörper (AA 14-389) (FITC)

TP53 Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh), Hund, Huhn, Chinese Hamster, Syrischer Goldhamster IF, FACS, ICC Wirt: Maus Monoclonal PAb240 FITC

Produktnummer ABIN4880089

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Bindungsspezifität
50

40

39

38

32

28

26

24

23

23

22

20

20

20

18

18

16

16

14

13

10

9

9

9

9

7

7

7

7

7

7

7

6

6

6

5

5

5

5

4

4

4

3

3

3

3

3

3

3

3
AA 14-389
Reaktivität
879

269

221

112

47

34

33

18

10

8

8

6

4

4

3

3

2

2

1

1

1

1

1

1
Human, Maus, Ratte, Affe, Rind (Kuh), Hund, Huhn, Chinese Hamster, Syrischer Goldhamster
Wirt
663

230

6

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
611

291

1
Monoklonal
Konjugat
501

49

36

26

25

25

24

24

22

22

22

13

13

13

13

13

12

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist konjugiert mit FITC
Applikation
710

328

249

217

200

145

124

123

119

65

55

35

20

17

13

12

12

10

9

8

6

4

3

3

2

2

2

2

1

1

1

1

1
Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Spezifität

This antibody recognises cellular tumour antigen p53, a 50 kDa transcription factor and major tumour suppressor that plays a major role in regulating cellular responses to DNA damage and other genomic aberrations. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. The Pab240 antibody recognizes an epitope between amino acids 156-214 on murine p53.

Aufreinigung

Purified on protein A from tissue culture supernatant.

Immunogen

Purified p53-b-galactosidase fusion protein containing p53 sequence from amino acids 14-389

Klon

PAb240

Isotyp

IgG1

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Applikationshinweise

Optimal antibody dilution should be determined by titration

Kommentare

Myeloma, fusion partners: Cells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Purified IgG conjugated to Fluoroscein using Innova Biosciences Lightning-Link®, supplied in Phosphate buffered saline (PBS) containing 0.09 % Sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

P53 (TP53 Produkte)

Synonyme

BCC7 antikoerper, LFS1 antikoerper, P53 antikoerper, TRP53 antikoerper, p53 antikoerper, Trp53 antikoerper, brp53 antikoerper, drp53 antikoerper, etID22686.5 antikoerper, fb40d06 antikoerper, wu:fb40d06 antikoerper, zgc:111919 antikoerper, Tp53 antikoerper, bbl antikoerper, bfy antikoerper, bhy antikoerper, p44 antikoerper, tp53 antikoerper, Xp53 antikoerper, TP53 antikoerper, tumor protein p53 antikoerper, cellular tumor antigen p53 antikoerper, transformation related protein 53 antikoerper, tumor protein p53 L homeolog antikoerper, TP53 antikoerper, CpipJ_CPIJ002758 antikoerper, Tp53 antikoerper, tp53 antikoerper, Trp53 antikoerper, tp53.L antikoerper

OMIM

191170

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt