IKBKB Antikörper (pTyr199)

Produktnummer ABIN2839600

Produktdetails anti-IKBKB Antikörper

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Bindungsspezifität: pTyr199

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKBKB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IKKb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y199 of human IKKb.

Klon: RB6996

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-IKBKB Antikörper (ABIN2839600)

Zhu, Moore, Morii, Howard, Culver, Arrendale, Reddy, Evers, Zhang, Sica, Chen, Sun, Fu, Khuri, Shin, Snyder, Shoji: "Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts." in: Current cancer drug targets, Vol. 14, Issue 4, pp. 380-93, (2014) (PubMed).

Details zu IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Andere Bezeichnung: IKKb (IKBKB Produkte)

Synonyme: ikk-beta antikoerper, ikk2 antikoerper, ikkb antikoerper, ikkbeta antikoerper, IKBKB antikoerper, IKKB antikoerper, CG4201 antikoerper, DIK antikoerper, DLAK antikoerper, DmIKK antikoerper, DmIKKBeta antikoerper, DmIKKb antikoerper, DmIKKbeta antikoerper, DmIkkbeta antikoerper, Dmel\\CG4201 antikoerper, Dmikkb antikoerper, Dmikkbeta antikoerper, IK antikoerper, IKK antikoerper, IKK-beta antikoerper, IKKb antikoerper, IKKbeta antikoerper, IRD-5 antikoerper, IRD5 antikoerper, Ik antikoerper, Ikkb antikoerper, Ikkbeta antikoerper, Ird-5 antikoerper, Ird5 antikoerper, LRK antikoerper, Lak antikoerper, anon-89Bd antikoerper, dIKK antikoerper, dIKK-beta antikoerper, dIKKbeta antikoerper, dLak antikoerper, dmIKKbeta antikoerper, ikk antikoerper, ird antikoerper, ird5/DmIkk[beta] antikoerper, IKK2 antikoerper, NFKBIKB antikoerper, AIM-1 antikoerper, AI132552 antikoerper, IKK-2 antikoerper, IKK[b] antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antikoerper, inhibitor of nuclear factor kappa B kinase subunit beta antikoerper, I-kappaB kinase beta antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antikoerper, inhibitor of kappaB kinase beta antikoerper, ikbkb.L antikoerper, IKBKB antikoerper, ikbkb antikoerper, IKKbeta antikoerper, Ikbkb antikoerper

Hintergrund: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the inhibitory I-kappa-B proteins by kinases (IKKa or IKKb) leads to the dissociation of the inhibitor/NF-kappa-B complex and marks the inhibitors for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs.

Molekulargewicht: 86564

Gen-ID: 3551

NCBI Accession: NP_001177649, NP_001229707, NP_001547

UniProt: O14920

Pathways: NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine