AKT1 Antikörper (phosphorylated)

Produktnummer ABIN2666092

Produktdetails anti-AKT1 Antikörper

Target: AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))

Bindungsspezifität: phosphorylated

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKT1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: This antibody was purified by affinity chromatography.

Klon: Poly6490

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store frozen at -20°C.

Details zu AKT1

Target: AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))

Andere Bezeichnung: Akt (AKT1 Produkte)

Synonyme: AKT antikoerper, CWS6 antikoerper, PKB antikoerper, PKB-ALPHA antikoerper, PRKBA antikoerper, RAC antikoerper, RAC-ALPHA antikoerper, Akt antikoerper, Rac antikoerper, PKB/Akt antikoerper, PKBalpha antikoerper, AKT/PKB antikoerper, AKT1 antikoerper, Akt/PKB antikoerper, Akt1 antikoerper, CG4006 antikoerper, D-Akt antikoerper, DAKT1 antikoerper, DAKT1/PKB antikoerper, DAkt antikoerper, DAkt1 antikoerper, DPKB antikoerper, DRAC-PK antikoerper, DRAC-PK66 antikoerper, DRAC-PK85 antikoerper, Dakt antikoerper, Dakt1 antikoerper, Dmel\\CG4006 antikoerper, Dpkb antikoerper, PKB/AKT antikoerper, PKB/dAKT antikoerper, RacPK antikoerper, akt antikoerper, akt1 antikoerper, dAKT antikoerper, dAKT/dPKB antikoerper, dAKT1 antikoerper, dAkt antikoerper, dAkt/PKB antikoerper, dAkt1 antikoerper, dPKB antikoerper, dakt antikoerper, dakt1 antikoerper, l(3)04226 antikoerper, l(3)89Bq antikoerper, p-Akt antikoerper, pAkt antikoerper, ACT-5 antikoerper, akt-1 antikoerper, pkb antikoerper, v-akt antikoerper, v-akt1 antikoerper, xAct antikoerper, ATAKT1 antikoerper, F18A8.2 antikoerper, F18A8_2 antikoerper, K+ transporter 1 antikoerper, POTASSIUM TRANSPORTER antikoerper, AKT serine/threonine kinase 1 antikoerper, thymoma viral proto-oncogene 1 antikoerper, CG4006 gene product from transcript CG4006-RE antikoerper, actin beta antikoerper, v-akt murine thymoma viral oncogene homolog 1 S homeolog antikoerper, v-akt murine thymoma viral oncogene homolog 1 antikoerper, K+ transporter 1 antikoerper, Serine/threonine-protein kinase akt-1 antikoerper, AKT1 antikoerper, Akt1 antikoerper, ACTB antikoerper, akt1.S antikoerper, akt1 antikoerper, KT1 antikoerper, akt-1 antikoerper

Hintergrund: Akt (also known as protein kinase B alpha) is a 60 kD serine/threonine specific kinase containing a pleckstrin domain. Akt plays a critical role in controlling survival and apoptosis. This kinase is ubiquitously expressed and translocates to the membrane upon activation. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI 3-kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4) and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2, responsible for phosphorylation of Akt at Ser473, has been identified as a mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor and Sin1. Activated Akt can then phosphorylate a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3,Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2). Akt promotes cell survival by inhibiting apoptosis through phosphorylation and by inactivation of several targets, including Bad, forkhead transcription factor, c-Raf and caspase-9. Akt also plays a critical role in cell growth by directly phosphorylating mTOR in a rapamycin-sensitive complex containing raptor. More importantly, Akt phosphorylates and inactivates tuberin (TSC2), an inhibitor of mTOR within the mTOR-raptor complex. The phosphor-Akt (S473) antibody specifically detects phosphorlated Akt at the Ser473 site.

Pathways: PI3K-Akt Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, AMPK Signaling, Interferon-gamma Pathway, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Water Deprivation, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGFR1 Specific Signals, VEGF Signaling, Warburg Effekt