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p53 Antikörper (AA 181-190)

TP53 Reaktivität: Human WB, IHC, IHC (p), IP, IHC (fro) Wirt: Maus Monoclonal DO-11 unconjugated

Produktnummer ABIN198283

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Bindungsspezifität
51

41

40

39

32

30

28

25

24

24

23

20

20

20

18

18

16

16

14

13

10

9

9

9

9

9

8

7

7

7

7

7

6

6

6

6

5

5

5

4

4

4

3

3

3

3

3

3

3

3
AA 181-190
Reaktivität
899

272

223

113

48

35

33

19

10

8

8

6

4

4

3

3

2

2

2

2

1

1

1

1

1
Human
Wirt
676

238

6

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
611

312

1
Monoklonal
Konjugat
516

49

40

26

25

25

24

24

23

22

22

13

13

13

13

13

13

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist unkonjugiert
Applikation
723

336

257

216

210

150

128

124

119

65

61

35

20

17

13

12

12

10

9

8

6

4

3

3

2

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

Recognizes the human Cellular tumor antigen p53, also known as p53 tumor suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kD cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-11 binds to an epitope within the central region of p53 between amino acids defining a cryptic epitope exposed in unfolded/ denatured p53. Nine isoforms of human p53 are produced by alternative splicing and promoter usage, the epitope recognized by clone DO-11 is present in all isoforms. Recognizes mutant forms of p53 and has been used successfully for detection of p53 by western blotting.

Aufreinigung

Purified IgG

Immunogen

Recombinant human p53 ( AA 181-190 ).

Type of Immunogen: Recombinant protein

Klon

DO-11

Isotyp

IgG1

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TP53 Reaktivität: Human WB, ELISA, IHC (p), PLA, RNAi Wirt: Maus Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Approved: IHC, IHC-Fr, IHC-P (1:1000), IP, WB (1:1000)

Usage: Immunohistology: This product does require antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose.

Kommentare

Target Species of Antibody: Human

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

Lot specific

Buffer

PBS,  pH 7.4, 0.09 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

4°C or -20°C, Avoid freeze-thaw cycles.
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

TP53 / p53 (TP53 Produkte)

Synonyme

BCC7 antikoerper, LFS1 antikoerper, P53 antikoerper, TRP53 antikoerper, p53 antikoerper, Trp53 antikoerper, brp53 antikoerper, drp53 antikoerper, etID22686.5 antikoerper, fb40d06 antikoerper, wu:fb40d06 antikoerper, zgc:111919 antikoerper, Tp53 antikoerper, bbl antikoerper, bfy antikoerper, bhy antikoerper, p44 antikoerper, tp53 antikoerper, Xp53 antikoerper, TP53 antikoerper, tumor protein p53 antikoerper, cellular tumor antigen p53 antikoerper, transformation related protein 53 antikoerper, tumor protein p53 L homeolog antikoerper, TP53 antikoerper, CpipJ_CPIJ002758 antikoerper, Tp53 antikoerper, tp53 antikoerper, Trp53 antikoerper, tp53.L antikoerper

Hintergrund

Name/Gene ID: TP53
Family: P53

Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1

Gen-ID

7157

UniProt

P04637

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt