LAG3 Protein (Fc Tag)

Produktnummer ABIN7320947

Produktdetails

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Protein-Typ: Recombinant

Spezies: Cynomolgus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses LAG3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Cynomolgus LAG-3/CD223 Protein (Fc Tag)

Sequenz: Ala18-His449(Pro74)

Produktmerkmale: Recombinant Cynomolgus LAG-3 Protein is produced by our Mammalian expression system and the target gene encoding Ala18-His449(Pro74) is expressed with a Fc tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution ofPBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: LAG-3/CD223 (LAG3 Produkte)

Synonyme: CD223 Protein, LAG-3 Protein, Ly66 Protein, lymphocyte activating 3 Protein, lymphocyte-activation gene 3 Protein, LAG3 Protein, Lag3 Protein

Hintergrund:

Background: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

Synonym: Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223

Molekulargewicht: 73.6 kDa

NCBI Accession: XP_005570011

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints