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Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag) Protein

LAG3 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Pubmed (1 reference)
Produktnummer ABIN2181447
$375.10
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle LAG3 Proteine anzeigen
    LAG3
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 23-450
    Spezies
    • 19
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    Human
    Quelle
    • 19
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses LAG3 Protein ist gelabelt mit His tag.
    Sequenz
    AA 23-450
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus, and has a calculated MW of 47 kDa. The predicted N-terminus is Leu 23. The reducing (R) protein migrates as 55-60 kDa in SDS-PAGE due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Yu, Huang, Chen, Liu, Wu, Pu, Wang, Kang, Zhou: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy." in: mAbs, Vol. 11, Issue 6, pp. 1139-1148, (2019) (PubMed).

  • Target
    LAG3
    Andere Bezeichnung
    LAG-3 (LAG3 Produkte)
    Synonyme
    CD223, LAG-3, Ly66, lymphocyte activating 3, lymphocyte-activation gene 3, LAG3, Lag3
    Hintergrund
    Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
    Molekulargewicht
    47.1 kDa
    NCBI Accession
    NP_002277
    UniProt
    P18627
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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