Tumor Necrosis Factor (TNF) (AA 77-233) (Active) Protein

Details zu Produkt Nr. ABIN2181831, Anbieter: Anmelden zum Anzeigen
Proteinname
  • DIF
  • TNF-alpha
  • TNFA
  • TNFSF2
  • RATTNF
  • Tnfa
  • tnf
  • TNF-a
  • TNFalpha
  • Tnfsf1a
  • TNFa
  • cTNF
  • Tnf-alpha
  • tnfa-like
  • TNF-ALPHA
  • dif
  • tnfa
  • xtnf
  • tnfsf2
  • tnf-alpha
  • Cachectin
  • tumor necrosis factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • tumor necrosis factor a (TNF superfamily, member 2)
  • TNF
  • Tnf
  • tnf
  • tnfb
  • tnf-alpha
  • LOC103694380
  • tnfa
Proteineigenschaft
AA 77-233
30
20
12
8
7
5
5
5
4
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Spezies
Human
117
61
32
9
7
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Quelle
HEK-293 Cells
177
28
19
6
3
3
2
2
1
1
1
1
1
Protein-Typ
Recombinant
Biologische Aktivität
Active
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Marke ActiveMax®
Produktmerkmale This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 18 kDa under reducing (R) condition (SDS-PAGE).
Reinheit >95 % as determined by SDS-PAGE.
Sterilität 0.22 μm filtered
Endotoxin-Niveau Less than 0.1 EU per μg by the LAL method.
Güteklasse HPLC verified
Proteinname
Hintergrund Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Molekulargewicht 17.4 kDa
NCBI Accession NP_000585
Pathways NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C in lyophilized state after receipt. For long term storage, upon reconstitution rhTNFa should be aliquot and store at -20°C or -80°C.
Bilder des Herstellers
SDS-PAGE (SDS) image for Tumor Necrosis Factor (TNF) (AA 77-233) (Active) protein (ABIN2181831) Human TNF-alpha (HPLC-verified) on SDS-PAGE under reducing (R) condition. The gel was...
Binding Studies (Bind) image for Tumor Necrosis Factor (TNF) (AA 77-233) (Active) protein (ABIN2181831) Immobilized Human TNF-alpha can bind Humira with a linear range of 0.04-0.6 ng/mL.
Allgemeine Veröffentlichungen Dowlati, Herrmann, Swardfager, Liu, Sham, Reim, Lanctôt: "A meta-analysis of cytokines in major depression." in: Biological psychiatry, Vol. 67, Issue 5, pp. 446-57, 2010 (PubMed).

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