IL-6 Protein (AA 25-211, Extracellular Domain) (Fc Tag)

Produktnummer ABIN1344242

Produktdetails

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: Extracellular Domain, AA 25-211

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL-6 Protein ist gelabelt mit Fc Tag.

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Maus

Produktmerkmale: The extracellular domain of mouse IL-6 (aa 25-211) is fused at the C-terminus to the Fc portion of human IgG2.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Promotes growth of hybridoma/plasma cells at concentration <0.1ng /ml.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 12 months

Antigendetails

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Andere Bezeichnung: IL-6 (IL6 Produkte)

Synonyme: BSF2 Protein, HGF Protein, HSF Protein, IFNB2 Protein, IL-6 Protein, Il-6 Protein, ILg6 Protein, Ifnb2 Protein, il6 Protein, CHIL-6 Protein, interleukin 6 Protein, interleukin-6 Protein, IL6 Protein, Il6 Protein, il-6 Protein, IL-6 Protein

Hintergrund: Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa-28 kDa phosphorylated and variably glycosylated molecule. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.

Molekulargewicht: 50kDa

UniProt: P08505

Pathways: TLR Signalweg, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome