Parkin Antikörper (AA 1-465)

Produktnummer ABIN7151093

Produktdetails anti-Parkin Antikörper

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Bindungsspezifität: AA 1-465

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Parkin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase parkin protein (1-465AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Andere Bezeichnung: PRKN (PARK2 Produkte)

Synonyme: CG10523 antikoerper, Dmel\\CG10523 antikoerper, Dpark antikoerper, SD01679 antikoerper, dpk antikoerper, AR-JP antikoerper, LPRS2 antikoerper, PDJ antikoerper, PRKN antikoerper, Park antikoerper, Prkn antikoerper, si:ch211-123f21.1 antikoerper, zgc:112390 antikoerper, pdr-1 antikoerper, PARK2 antikoerper, parkin antikoerper, parkin RBR E3 ubiquitin protein ligase antikoerper, Parkinson disease (autosomal recessive, juvenile) 2, parkin antikoerper, park antikoerper, PRKN antikoerper, Prkn antikoerper, prkn antikoerper, CpipJ_CPIJ014867 antikoerper, Park2 antikoerper

Hintergrund:

Background: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as \\\'Lys-48\\\'-linked and \\\'Lys-63\\\'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating \\\'Lys-63\\\'-linked polyubiquitination of misfolded proteins such as PARK7: \\\'Lys-63\\\'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates \\\'Lys-63\\\'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates \\\'Lys-48\\\'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome, possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Aliases: AR JP antibody, E3 ubiquitin ligase antibody, E3 ubiquitin protein ligase parkin antibody, E3 ubiquitin-protein ligase parkin antibody, FRA6E antibody, LPRS 2 antibody, LPRS2 antibody, PARK 2 antibody, Park2 antibody, Parkin 2 antibody, Parkinson disease (autosomal recessive juvenile) 2 antibody, Parkinson disease (autosomal recessive, juvenile) 2, parkin antibody, Parkinson disease protein 2 antibody, Parkinson juvenile disease protein 2 antibody, Parkinson protein 2 E3 ubiquitin protein ligase antibody, Parkinson protein 2, E3 ubiquitin protein ligase (parkin) antibody, PDJ antibody, PRKN 2 antibody, PRKN antibody, PRKN2 antibody, PRKN2_HUMAN antibody, Ubiquitin E3 ligase PRKN antibody

UniProt: O60260

Pathways: Autophagie, Ubiquitin Proteasome Pathway