PARK2
Reaktivität: Human
WB, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Titration of the Parkin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:250-1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the Parkin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
Parkin (PARK2)
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.