NAIP Antikörper (C-Term)

Produktnummer ABIN6990465

Produktdetails anti-NAIP Antikörper

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Bindungsspezifität: AA 1200-1250, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Minor, lower molecular weight bands may represent alternately spliced forms.

Aufreinigung: NAIP Antibody is affinity chromatography purified via peptide column.

Immunogen: NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP. The immunogen is located within amino acids 1200 - 1250 of NAIP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NAIP antibody can be used for the detection of NAIP by Western blot at 0.5 to 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NAIP Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NAIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Andere Bezeichnung: NAIP (NAIP Produkte)

Synonyme: BIRC1 antikoerper, NLRB1 antikoerper, psiNAIP antikoerper, AV364616 antikoerper, Birc1a antikoerper, D13Lsd1 antikoerper, Naip antikoerper, Naip-rs1 antikoerper, NLR family apoptosis inhibitory protein antikoerper, NLR family, apoptosis inhibitory protein 1 antikoerper, NAIP antikoerper, Naip1 antikoerper

Hintergrund: NAIP Antibody: Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR), these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.

Molekulargewicht: Predicted: 137, 154 kDa

Observed: 155 kDa

Gen-ID: 4671

UniProt: Q13075

Pathways: Apoptose, Inflammasome