NAIP Antikörper (C-Term)

Produktnummer ABIN500306

Der Kaninchen Polyklonal anti-NAIP Antikörper wird verwendet zum Nachweis von NAIP in Proben von Human. Er wurde validiert für WB, IF und EIA.

Kurzübersicht für NAIP Antikörper (C-Term) (ABIN500306)

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-NAIP Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects NAIP at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Peptide affinity chromatography

Immunogen: NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Andere Bezeichnung: NAIP

Hintergrund: Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy (1,2). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR), these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO (4), suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported (5).Synonyms: BIRC1, Baculoviral IAP repeat-containing protein 1

Gen-ID: 4671

UniProt: Q13075

Pathways: Apoptose, Inflammasome