IL-1 beta Antikörper (Internal Region)

Produktnummer ABIN6262623

Produktdetails anti-IL-1 beta Antikörper

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-1 beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: IL1 beta Antibody detects endogenous levels of total IL1 beta.

Homologie: Horse,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL1 beta, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-IL-1 beta Antikörper (ABIN6262623)

Zhu, Chen, Dai, Zheng, Jiang, Xu, Sheng, Guo, Dan, Liang, Li: "Chronic lead exposure enhances the sympathoexcitatory response associated with P2X4 receptor in rat stellate ganglia." in: Environmental toxicology, Vol. 33, Issue 6, pp. 631-639, (2018) (PubMed).

Hu, Cheng, Huang, Cai, Lian, Wang, Gao: "Effects of Xin-Ji-Er-Kang on heart failure induced by myocardial infarction: Role of inflammation, oxidative stress and endothelial dysfunction." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 42, pp. 245-257, (2018) (PubMed).

Sheng, Wang, Guo, Xu, Jiang, Zheng, Xu, Zhang, Che, Liang, Zhu, Li: "Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 3, pp. 986-998, (2018) (PubMed).

Zhu, Xu, Lv, He, Ye, Wang, Hu: "miR-199b-5p Regulates Immune-Mediated Allograft Rejection after Lung Transplantation Through the GSK3β and NF-κB Pathways." in: Inflammation, Vol. 41, Issue 4, pp. 1524-1535, (2018) (PubMed).

Zhu, Shi, Lv, Li, Pan, Chen, Zhao, Yan, Chen, Loake, Niu, Zeng, Xu: "Loss of NLRP3 Function Alleviates Murine Hepatic Graft-versus-Host Disease." in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, (2018) (PubMed).

Guo, Sheng, Dan, Xu, Zhang, Ji, Wang, Xu, Che, Li, Liang, Li: "Involvement of P2Y12 receptor of stellate ganglion in diabetic cardiovascular autonomic neuropathy." in: Purinergic signalling, (2018) (PubMed).

Feng, Gao, Cui, Li, Li, Cui, Cui: "Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway." in: Cellular and molecular neurobiology, Vol. 37, Issue 1, pp. 155-168, (2017) (PubMed).

Ding, Xu, Wang, Zhang: "Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 3136-43, (2016) (PubMed).

Feng, Cui, Gao, Li, Li, Jiang, Tian, Wang, Cui, Cui: "Resveratrol attenuates neuronal autophagy and inflammatory injury by inhibiting the TLR4/NF-κB signaling pathway in experimental traumatic brain injury." in: International journal of molecular medicine, Vol. 37, Issue 4, pp. 921-30, (2016) (PubMed).

Details zu IL-1 beta

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Andere Bezeichnung: IL1B (IL1B Produkte)

Synonyme: IL-1 antikoerper, IL1-BETA antikoerper, IL1F2 antikoerper, IL-1BETA antikoerper, IL1beta antikoerper, il1-b antikoerper, zgc:111873 antikoerper, IL-1B antikoerper, IL-1beta antikoerper, Il-1b antikoerper, IL1B antikoerper, IL-1 beta antikoerper, IL-1b antikoerper, interleukin 1 beta antikoerper, interleukin 1, beta antikoerper, IL1B antikoerper, il1b antikoerper, Il1b antikoerper

Hintergrund:

Description: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Gene: IL1B

Molekulargewicht: 30 kDa(precursor),17kDa(mature)

Gen-ID: 3553

UniProt: P01584

Pathways: NF-kappaB Signalweg, Interferon-gamma Pathway, TLR Signalweg, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagie, Cancer Immune Checkpoints, Inflammasome