NLRP1 Antikörper
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- Target Alle NLRP1 Antikörper anzeigen
- NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NLRP1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- NLR family, pyrin domain containing 1
- Isotyp
- IgG
- Top Product
- Discover our top product NLRP1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05757( NLRP1 Antibody) at dilution of 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
- Andere Bezeichnung
- NLRP1 (NLRP1 Produkte)
- Synonyme
- CARD7 antikoerper, CIDED antikoerper, CLR17.1 antikoerper, DEFCAP antikoerper, DEFCAP-L/S antikoerper, NAC antikoerper, NALP1 antikoerper, PP1044 antikoerper, SLEV1 antikoerper, VAMAS1 antikoerper, NLR family pyrin domain containing 1 antikoerper, NLRP1 antikoerper, Nlrp1 antikoerper
- Hintergrund
- Synonyms:CARD7, CLR17.1, DEFCAP, DEFCAP L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, NLRP1, PP1044, SLEV1, VAMAS1 Background:As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death(PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide(MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner(PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin(PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release(PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP(PubMed:17349957). Binds ATP(PubMed:11113115, PubMed:15212762).
- Molekulargewicht
- 160-166 kDa
- Gen-ID
- 22861
- UniProt
- Q9C000
- Pathways
- Positive Regulation of Endopeptidase Activity, Inflammasome
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