NFKBIA Antikörper (pTyr42)

Produktnummer ABIN498722

Produktdetails anti-NFKBIA Antikörper

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Bindungsspezifität: pTyr42

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFKBIA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of IkappaB-alpha protein only when phosphorylated at Tyr42.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu NFKBIA

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Andere Bezeichnung: NFKBIA / IKBA (NFKBIA Produkte)

Synonyme: IKBA antikoerper, MAD-3 antikoerper, NFKBI antikoerper, AI462015 antikoerper, Nfkbi antikoerper, RL/IF-1 antikoerper, ECI-6/IKBA antikoerper, NFKBIA antikoerper, ikbaB antikoerper, wu:fb81f08 antikoerper, zgc:56666 antikoerper, zgc:77616 antikoerper, ikbaA antikoerper, wu:fj16a07 antikoerper, zgc:85769 antikoerper, NFKB inhibitor alpha antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a antikoerper, NFKBIA antikoerper, Nfkbia antikoerper, nfkbiab antikoerper, nfkbiaa antikoerper

Hintergrund: On the basis of both functional and structural considerations, members of the IkappaB family of proteins can be divided into four groups. The first of these groups, IkappaB-alpha (a 35-37 kDa protein), includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkappaB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to kappaB sites, suggesting that the IkappaB-alpha family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IkappaB family is represented by a 45 kDa protein designated IkappaB-beta. The third group of IkappaB proteins is represented by IkappaB-gamma, a 70 kDa protein identical in sequence with the Cterminal domain of the p110 precursor of NFkappaB p50 and expressed predominantly in lymphoid cells.Synonyms: I kappa B-alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, MAD3, Major histocompatibility complex enhancer-binding protein MAD3, NF-kappa-B inhibitor alpha, NFKBI

Molekulargewicht: approx. 36 kDa

Gen-ID: 4792

NCBI Accession: NP_065390

UniProt: P25963

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling