Patched 1 Antikörper

Produktnummer ABIN4904887

Produktdetails anti-Patched 1 Antikörper

Target: Patched 1 (PTCH1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Patched1 and 2 (PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the receiving receptors for members of the Hedgehog family of proteins (1-4). In the absence of Hedgehog proteins, PTCH suppresses the otherwise constitutively active signaling receptor Smoothened (Smo) so that the Hedgehog signaling pathway is in the off state (5,6). Deactivating mutations that impair the ability of PTCH1 to suppress Smo are frequently found in patients with nevoid basal cell carcinoma syndrome (7,8). PTCH proteins have a sterol-sensing domain (SSD) also found in several proteins that function in cholesterol homeostasis, such as HMGCR (3-hydroxy-3-methylglutaryl coenzyme A-reductase) and SCAP (sterol regulatory element-binding protein-cleavage activating protein). However, the role of the SSD in Patched proteins is not clear (9,10).PTCH1 itself is a target of Hedgehog signaling (11), with elevated PTCH1 expression as a surrogate marker for Hedgehog pathway activation (12-14).

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human PTCH1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH (PTCH1 Produkte)

Synonyme: BCNS antikoerper, HPE7 antikoerper, NBCCS antikoerper, PTC antikoerper, PTC1 antikoerper, PTCH antikoerper, PTCH11 antikoerper, lep antikoerper, ptc1 antikoerper, ptc2 antikoerper, Ptch antikoerper, Ptch2 antikoerper, Ptc-1 antikoerper, XPtc1 antikoerper, patched antikoerper, patched1 antikoerper, A230106A15Rik antikoerper, Ptc antikoerper, Ptc1 antikoerper, mes antikoerper, patched 1 antikoerper, patched 1 L homeolog antikoerper, Protein patched homolog 1 antikoerper, PTCH1 antikoerper, ptch1 antikoerper, Ptch1 antikoerper, ptch1.L antikoerper, ptc-1 antikoerper

Gen-ID: 5727

UniProt: Q13635

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation