Patched 1 Antikörper (C-Term)

Produktnummer ABIN2773841

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Patched 1 Antikörper wird verwendet zum Nachweis von Patched 1 in Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Meerschweinchen und Kaninchen. Er wurde validiert für WB und IHC.

Kurzübersicht für Patched 1 Antikörper (C-Term) (ABIN2773841)

Target: Patched 1 (PTCH1)

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Patched 1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PTCH1 Antibody - C-terminal region

Sequenz: TILGVLNGLV LLPVLLSFFG PYPEVSPANG LNRLPTPSPE PPPSVVRFAM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PTCH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PTCH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44249-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Patched 1 Antikörper (ABIN2773841)

Meerang, Bérard, Felley-Bosco, Lauk, Vrugt, Boss, Kenkel, Broggini-Tenzer, Stahel, Arni, Weder, Opitz: "Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma." in: Molecular cancer therapeutics, Vol. 15, Issue 5, pp. 1095-105, (2016) (PubMed).

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH1

Hintergrund:

Background Information: PTCH1 is a member of the patched gene family. The protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. It functions as a tumor suppressor. Mutations of its gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly.

Gene Name: Patched 1

Alternative Symbols: PTC, BCNS, PTC1, PTCH, NBCCS

Protein Name: Patched EMBL AAR21240.1

Molekulargewicht: 37kDa

Gen-ID: 5727

UniProt: Q6TKP8

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation