TNFRSF1B Antikörper (N-Term)

Produktnummer ABIN2789622

Produktdetails anti-TNFRSF1B Antikörper

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 86%, Rabbit: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFRSF1B. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 461 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TNFRSF1B Antikörper (ABIN2789622)

Droessler, Cornelius, Boehm, Stein, Brunner, Amasheh: "Barrier Perturbation in Porcine Peyer's Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins." in: Frontiers in physiology, Vol. 13, pp. 889552, (2022) (PubMed).

Droessler, Cornelius, Markov, Amasheh: "Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1." in: International journal of molecular sciences, Vol. 22, Issue 16, (2021) (PubMed).

Details zu TNFRSF1B

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Andere Bezeichnung: TNFRSF1B (TNFRSF1B Produkte)

Synonyme: CD120b antikoerper, TBPII antikoerper, TNF-R-II antikoerper, TNF-R75 antikoerper, TNFBR antikoerper, TNFR1B antikoerper, TNFR2 antikoerper, TNFR80 antikoerper, p75 antikoerper, p75TNFR antikoerper, TNF-RII/TNFRSF1B antikoerper, TNFR-II antikoerper, TNFRSF1B antikoerper, TNF-R2 antikoerper, TNF-alphaR2 antikoerper, TNFRII antikoerper, TNFalpha-R2 antikoerper, Tnfr-1 antikoerper, Tnfr2 antikoerper, rank antikoerper, zgc:163064 antikoerper, TNF receptor superfamily member 1B antikoerper, tumor necrosis factor receptor superfamily, member 1b antikoerper, tumor necrosis factor receptor superfamily, member 1B antikoerper, TNFRSF1B antikoerper, Tnfrsf1b antikoerper, tnfrsf1b antikoerper

Hintergrund: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Alias Symbols: CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Protein Interaction Partner: LTA, TNF, ADAM17, CSNK1A1, ZNF420, UBQLN1, TRAF1, PKN1, CD14, RIPK1, TRADD, TRAF2, TNFRSF1A, CHUK, TRAF6, TRAF3, ASB3, UBC, HIVEP3, TRAIP, TDP2, CAV1, STAT1, BMX, FANCD2, KRT18, SMURF2, TRIM37, TNFRSF1B,
Protein Size: 461

Molekulargewicht: 46 kDa

Gen-ID: 7133

NCBI Accession: NM_001066, NP_001057

UniProt: P20333

Pathways: NF-kappaB Signalweg, Apoptose, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway