GTPase NRas Antikörper (Middle Region)

Produktnummer ABIN971288

Produktdetails anti-GTPase NRas Antikörper

Target: GTPase NRas (NRAS)

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTPase NRas Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against NRAS. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 189 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GTPase NRas

Target: GTPase NRas (NRAS)

Andere Bezeichnung: NRAS (NRAS Produkte)

Synonyme: NRAS antikoerper, AV095280 antikoerper, N-ras antikoerper, ALPS4 antikoerper, NRAS1 antikoerper, NS6 antikoerper, N-RAS antikoerper, fj99a10 antikoerper, wu:fj99a10 antikoerper, zgc:100761 antikoerper, zras-b1 antikoerper, H-RAS antikoerper, HRAS antikoerper, GTPase NRas antikoerper, neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog antikoerper, NRAS proto-oncogene, GTPase antikoerper, neuroblastoma ras oncogene antikoerper, neuroblastoma RAS viral oncogene homolog antikoerper, Tsp_01117 antikoerper, nras.L antikoerper, Nras antikoerper, NRAS antikoerper, nras antikoerper

Hintergrund: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: UBC, MDM2, RGL2, VAT1, RNASEH2B, SPATS2, CD2AP, ELAVL1, SRI, RPS20, DNAJB1, EEF1A1, RAP1GDS1, RASGRP2, PLCE1, SMURF2, RASSF5, RACGAP1, SHOC2, SMAD4, ARHGAP4, PIK3CA, RAF1, BCL2, ACVR1, PIK3CG, MLLT4,
Protein Size: 189

Molekulargewicht: 21 kDa

Gen-ID: 4893

NCBI Accession: NM_002524, NP_002515

UniProt: P01111

Pathways: p53 Signalweg, MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling