GTPase NRas Antikörper (AA 147-179)

Produktnummer ABIN3031131

Produktdetails anti-GTPase NRas Antikörper

Target: GTPase NRas (NRAS)

Bindungsspezifität: AA 147-179

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTPase NRas Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Kreuzreaktivität (Details): Expected species reactivity: Pig

Aufreinigung: Purified

Immunogen: A portion of amino acids 147-179 from the human protein was used as the immunogen for this NRAS antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the NRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the NRAS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu GTPase NRas

Target: GTPase NRas (NRAS)

Andere Bezeichnung: NRAS (NRAS Produkte)

Synonyme: NRAS antikoerper, AV095280 antikoerper, N-ras antikoerper, ALPS4 antikoerper, NRAS1 antikoerper, NS6 antikoerper, N-RAS antikoerper, fj99a10 antikoerper, wu:fj99a10 antikoerper, zgc:100761 antikoerper, zras-b1 antikoerper, H-RAS antikoerper, HRAS antikoerper, GTPase NRas antikoerper, neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog antikoerper, NRAS proto-oncogene, GTPase antikoerper, neuroblastoma ras oncogene antikoerper, neuroblastoma RAS viral oncogene homolog antikoerper, Tsp_01117 antikoerper, nras.L antikoerper, Nras antikoerper, NRAS antikoerper, nras antikoerper

Hintergrund: NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).

UniProt: P01111

Pathways: p53 Signalweg, MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling