IL4 Receptor Antikörper (C-Term)

Produktnummer ABIN2788560

Produktdetails anti-IL4 Receptor Antikörper

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL4 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GLDREPPRSP QSSHLPSSSP EHLGLEPGEK VEDMPKPPLP QEQATDPLVD

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against IL4R. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL4R

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Andere Bezeichnung: IL4R (IL4R Produkte)

Synonyme: IL4R antikoerper, il-4ra antikoerper, zgc:113063 antikoerper, CD124 antikoerper, IL-4RA antikoerper, IL4RA antikoerper, Il4ra antikoerper, IL4 antikoerper, Il4r antikoerper, interleukin 4 receptor antikoerper, interleukin 4 receptor, tandem duplicate 1 antikoerper, interleukin 4 receptor, alpha antikoerper, IL4R antikoerper, il4r.1 antikoerper, Il4r antikoerper, Il4ra antikoerper

Hintergrund: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Protein Interaction Partner: UBC, JAK3, CD40, STAT6, JAK2, JAK1, IL2RG, SOCS5, KAT5, HGS, ARIH2, INPP5D, DOK2, IRS2, SHC1, IL13RA1, NCF1, FES, PRKCZ, GNB2L1, PTPN6, PTPN11, IL4, IL13, IRS1,
Protein Size: 825

Molekulargewicht: 87 kDa

Gen-ID: 3566

UniProt: P24394

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process