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TNFRSF1B Antikörper (Tumor Necrosis Factor Receptor Superfamily, Member 1B) (FITC) Primary Antibody

TNFRSF1B Reaktivität: Maus Func, IA, FACS, IP, WB Wirt: Ratte Monoclonal HM102 FITC
Pubmed (2 Referenzen)
Produktnummer ABIN2191751
$885.41
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle TNFRSF1B Antikörper anzeigen
    TNFRSF1B
    Reaktivität
    • 91
    • 64
    • 36
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Maus
    Wirt
    • 66
    • 35
    • 10
    • 7
    • 3
    • 1
    • 1
    Ratte
    Klonalität
    • 66
    • 57
    Monoklonal
    Konjugat
    • 73
    • 21
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser TNFRSF1B Antikörper ist konjugiert mit FITC
    Applikation
    • 85
    • 42
    • 41
    • 37
    • 35
    • 22
    • 20
    • 17
    • 14
    • 8
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    HM102
  • Applikationshinweise
    For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive RAW264.7 cells control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Brekke, Sagen, Bjerve: "Specificity of endogenous fatty acid release during tumor necrosis factor-induced apoptosis in WEHI 164 fibrosarcoma cells." in: Journal of lipid research, Vol. 40, Issue 12, pp. 2223-33, (2000) (PubMed).

    Tacchini-Cottier, Vesin, Redard, Buurman, Piguet: "Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 6182-6, (1998) (PubMed).

  • Target
    TNFRSF1B
    Andere Bezeichnung
    Tnf-Rii (TNFRSF1B Produkte)
    Synonyme
    CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, TNF-RII/TNFRSF1B, TNFR-II, TNFRSF1B, TNF-R2, TNF-alphaR2, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, rank, zgc:163064, TNF receptor superfamily member 1B, tumor necrosis factor receptor superfamily, member 1b, tumor necrosis factor receptor superfamily, member 1B, TNFRSF1B, Tnfrsf1b, tnfrsf1b
    Hintergrund
    The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. TNF-alpha is an important signalling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNFRII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNFRII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is an agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII. Aliases Tumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor
    Pathways
    NF-kappaB Signalweg, Apoptose, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway
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