CD130/gp130 Antikörper (PE)

Produktnummer ABIN1105853

Produktdetails anti-CD130/gp130 Antikörper (PE)

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD130/gp130 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Immunogen: Mouse CD130 transfected cells

Klon: RMb1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 50 tests in 1 mLvolume of PBS, 0.09 % NaN3, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Andere Bezeichnung: CD130 / IL6ST (IL6ST Produkte)

Synonyme: CD130 antikoerper, CDW130 antikoerper, GP130 antikoerper, IL-6RB antikoerper, 5133400A03Rik antikoerper, AA389424 antikoerper, BB405851 antikoerper, D13Ertd699e antikoerper, gp130 antikoerper, Ac1055 antikoerper, Gp130 antikoerper, Il-6rb antikoerper, IL-6 antikoerper, interleukin 6 signal transducer antikoerper, IL6ST antikoerper, Il6st antikoerper, il6st antikoerper

Hintergrund: The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signalling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta

Gen-ID: 10090

UniProt: Q00560

Pathways: JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints