CD130/gp130 Antikörper (AA 678-857)

Produktnummer ABIN7268003

Produktdetails anti-CD130/gp130 Antikörper

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Bindungsspezifität: AA 678-857

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD130/gp130 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: [KO Validated] IL6ST Rabbit pAb

Sequenz: PSISSSDENE SSQNTSSTVQ YSTVVHSGYR HQVPSVQVFS RSESTQPLLD SEERPEDLQL VDHVDGGDGI LPRQQYFKQN CSQHESSPDI SHFERSKQVS SVNEEDFVRL KQQISDHISQ SCGSGQMKMF QEVSAADAFG PGTEGQVERF ETVGMEAATD EGMPKSYLPQ TVRQGGYMPQ

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Güteklasse: KO Validated

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 678-857 of human IL6ST (NP_001177910.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Andere Bezeichnung: IL6ST (IL6ST Produkte)

Synonyme: CD130 antikoerper, CDW130 antikoerper, GP130 antikoerper, IL-6RB antikoerper, 5133400A03Rik antikoerper, AA389424 antikoerper, BB405851 antikoerper, D13Ertd699e antikoerper, gp130 antikoerper, Ac1055 antikoerper, Gp130 antikoerper, Il-6rb antikoerper, IL-6 antikoerper, interleukin 6 signal transducer antikoerper, IL6ST antikoerper, Il6st antikoerper, il6st antikoerper

Hintergrund: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.,IL6ST,CD130,CDW130,GP130,IL-6RB,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,CD markers,Cytokines,IL-6 Receptor Signaling Pathway,Cardiovascular,Heart,Hypertrophy,IL6ST

Molekulargewicht: 103kDa

Gen-ID: 3572

UniProt: P40189

Pathways: JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints