Proprotein Convertase Subtilisin/kexin Type 9 Proteine (PCSK9)

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Zusätzlich bieten wir Ihnen PCSK9 Antikörper (168) und PCSK9 Kits (87) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top PCSK9 Proteine auf antikoerper-online.de

Showing 10 out of 62 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$228.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
HEK-293 Cells Maus His tag 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$310.00
Details
HEK-293 Cells Human His tag 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$310.00
Details
Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$228.80
Details
Human Cells Rhesusaffen His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
$547.80
Details
HEK-293 Cells Maus Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
$222.28
Details
HEK-293 Cells Human His tag Human PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. Immobilized Human LDL R, His Tag (Cat# LDR-H5224) at 10 μg/mL (100 μl/well) can bind Human PCSK9, His Tag (Cat# PC9-H5223 ) with a linear range of 0.05-0.5 μg/mL. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$350.90
Details

PCSK9 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Am meisten referenzierte PCSK9 Proteine

  1. Human PCSK9 Protein expressed in HEK-293 Cells - ABIN2181580 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) PCSK9 Protein expressed in Human Cells - ABIN2007572 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartnern

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. Mutation spectrum and genotype-phenotype correlation was analyzed in patients with familial hypercholesterolemia in Chinese population.

  2. Given that overexpression of these LOF PCSK9 variants does not cause UPR activation under normal homeostatic conditions, therapeutic strategies aimed at blocking the autocatalytic cleavage of PCSK9 in the ER represent a viable strategy for reducing circulating PCSK9

  3. PCSK9 was inconsistently associated with cardiovascular (CV) events in populations with type 2 diabetes. The association may depend on the level of CV risk and the background treatment.

  4. These findings support a model in which SURF4 functions as an endoplasmic reticulum cargo receptor mediating the efficient cellular secretion of PCSK9.

  5. A long-term physical activity caused increase in PCSK9 blood levels.

  6. The present study shows that serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with coronary artery disease risk in Southern Chinese Han population, and that serum PCSK9 levels are positively associated with AIP

  7. In Japanese male subjects, the concentrations of serum PCSK9 and TBIL were correlated with periodontal parameters.

  8. C679X loss-of-function PCSK9 variant lowers fasting glucose levels.

  9. There was no protective or no deleterious effect of carrying PCSK9 LOF mutations on AD [Alzheimer disease]prevalence nor on age of onset, even when stratified by apolipoprotein E epsilon 4 genotype or by gender. Conclusion: Our data indicate that carrying PCSK9 LOF mutations has a neutral effect on neurocognitive health and the prevalence of AD [Alzheimer disease].

  10. High serum PCSK9 levels predict acute coronary syndrome occurrence at 24-month follow-up after carotid endarterectomy in patients with severe carotid artery stenosis.

  11. Taken together, the present study provides evidence of a pro-inflammatory action of PCSK9 on macrophages, mainly dependent by the LDLR.

  12. HepG2 cell lines transfected with siRNA directed to PCSK9 were challenged with Hcy, homocysteine thiolactone (HTL), testosterone, 5alpha-dihydroxytestosterone (5alpha-DHT), or estradiol for 24h, leading to an overt expression of PCSK9 and down-regulated expression of LDLR.

  13. Plasma PCSK9 levels and lipoprotein distribution are preserved in hypolipoproteinemia carriers.

  14. Inverse correlation between PCSK9 and CD36 in hypertrophic adipocytes may be associated with AAA development.

  15. Plasma Lp(a) level was associated with PCSK9 in patients with heterozygous familial hypercholesterolemia

  16. Authors performed an analysis of public databases and literature for every variant published associated with FH, in the genes LDLR, APOB, and PCSK9.

  17. PCSK9 levels increase as glucose metabolism deteriorated. Serum PCSK9 levels positively correlated with 2-hPG (2-h postchallenge plasma glucose) in Chinese Han patients with glucose metabolic diseases.

  18. PCSK9i-treated patients had higher rates of cardiovascular comorbidities.

  19. PCSK9 overexpression in the aorta may promote acute aortic dissection.

  20. High PCSK9 expression is associated with metabolic syndrome.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. Given that overexpression of these LOF PCSK9 variants does not cause UPR activation under normal homeostatic conditions, therapeutic strategies aimed at blocking the autocatalytic cleavage of PCSK9 in the ER represent a viable strategy for reducing circulating PCSK9

  2. Data suggest that expression of Pcsk9 and Ldlr in liver and pancreas can be regulated by dietary measures; here, dietary supplementation with quercetin-3-glucoside modulates expression of Pcsk9 and Ldlr in prevention of hyperlipidemia and hyperinsulinemia induced by high dietary cholesterol. (Pcsk9 = proprotein convertase subtilisin/kexin type-9; Ldlr = low-density lipoprotein receptor)

  3. The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia.

  4. It was concluded that quercetin inhibits oxLDLinduced lipid droplets in RAW264.7 cells by upregulation of ABCAl, ABCG1, LXRalpha and downregulation of PCSK9, p53, p21 and p16.

  5. PCSK9 overexpression in the aorta may promote acute aortic dissection.

  6. Genetically determined PCSK9 deficiency might be associated with ectopic fat accumulation.

  7. The present study aimed to explore the direct toxicity of proprotein convertase subtilisin/kexin type 9 (PCSK9) to atherosclerosis (AS) and its association with apoptotic endothelial cells.

  8. present anti-PCSK9 vaccine induced long-lasting anti-PCSK9 antibody production and improved lipoprotein profiles. Thus, anti-PCSK9 vaccine could become a new option for the treatment of dyslipidemia as a long-acting therapy in future

  9. PCSK9 may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4/NF-kappaB signaling pathway.

  10. PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall

  11. PCSK9 inhibits lipoprotein(a) clearance through the LDLR.

  12. Use Crispr-Cas system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  13. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  14. These observations suggest positive feedback interplay between SMC-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  15. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE(-/-) mice.

  16. Adeno-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  17. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR degradation and promoting LDLR-dependent hepatic cholesterol uptake.

  18. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

  19. PCSK9 increases hepatic lipid and lipoprotein production via apoE- and LDLR-dependent mechanisms

  20. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. the PCSK9-gain-of-function mutation induces rapid development of atherosclerosis in peripheral vessels of Ossabaw pigs, which is exacerbated by a high-cholesterol diet.

PCSK9 Protein Überblick

Protein Überblick

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Genbezeichner und Symbole assoziert mit PCSK9

  • proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L)
  • proprotein convertase subtilisin/kexin type 9 (pcsk9)
  • proprotein convertase subtilisin/kexin type 9 (PCSK9)
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9)
  • AI415265 Protein
  • AI747682 Protein
  • FH3 Protein
  • HCHOLA3 Protein
  • LDLCQ1 Protein
  • NARC-1 Protein
  • Narc1 Protein
  • PC9 Protein

Bezeichner auf Proteinebene für PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPEZIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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