Proprotein Convertase Subtilisin/kexin Type 9 Proteine (PCSK9)

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family.

alle Proteine anzeigen Gen GeneID UniProt
Human PCSK9 PCSK9 255738 Q8NBP7
Maus PCSK9 PCSK9 100102 Q80W65
Ratte PCSK9 PCSK9 298296 P59996
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Top PCSK9 Proteine auf antikoerper-online.de

Showing 10 out of 66 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$547.80
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$228.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
HEK-293 Cells Human His tag 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$310.00
Details
HEK-293 Cells Maus His tag 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$310.00
Details
Human Cells Ratte His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$228.80
Details
Human Cells Rhesusaffen His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
HEK-293 Cells Maus Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
$226.22
Details
HEK-293 Cells Human His tag Human PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. Immobilized Human LDL R, His Tag (Cat# LDR-H5224) at 10 μg/mL (100 μl/well) can bind Human PCSK9, His Tag (Cat# PC9-H5223 ) with a linear range of 0.05-0.5 μg/mL. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details

Am meisten referenzierte PCSK9 Proteine

  1. Human PCSK9 Protein expressed in HEK-293 Cells - ABIN2181580 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) PCSK9 Protein expressed in Human Cells - ABIN2007572 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartnern

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. In conclusion, PCSK9 inhibitors such as alirocumab may be an excellent lipid lowering agent in patients with statin intolerance and myotonic dystrophy.

  2. Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD; phase 2) and RUTHERFORD-2 (phase 3).

  3. We present a case of homozygous familial defective apolipoprotein B-100 (zeige APOB Proteine) due to APOB (zeige APOB Proteine) R3500Q (rs5742904) treated with evolocumab ..Identification of a patient homozygous for familial defective apolipoprotein B-100 (zeige APOB Proteine)(FDB) and successful treatment with PCSK9 inhibition

  4. A complex link between hepatitis C virus infection and PCSK9 has emerged, in which a bidirectional loop of interactions is conceivable. (Review)

  5. Genetically determined PCSK9 deficiency might be associated with ectopic fat accumulation.

  6. These results suggest that PCSK9 rs7552841 is associated with plasma lipids profiles only in female adolescents, but not in male students. This association can be modified and negated by posttraumatic stress disorder.

  7. PCSK9 carriers tended to be associated with an increased response to simvastatin therapy

  8. PCSK9 polymorphism may affect HIV pathogenesis, particularly in HIV/hepatitis C coinfected women. A likely mechanism for this effect is PCSK9-mediated regulation of cholesterol metabolism.

  9. There was no relationship between plasma PCSK9 levels and arterial stiffness.

  10. PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, body weight and an increased risk of type 2 diabetes.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. Genetically determined PCSK9 deficiency might be associated with ectopic fat accumulation.

  2. The present study aimed to explore the direct toxicity of proprotein convertase subtilisin/kexin type 9 (PCSK9) to atherosclerosis (AS) and its association with apoptotic endothelial cells.

  3. present anti-PCSK9 vaccine induced long-lasting anti-PCSK9 antibody production and improved lipoprotein profiles. Thus, anti-PCSK9 vaccine could become a new option for the treatment of dyslipidemia as a long-acting therapy in future

  4. PCSK9 may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4 (zeige TLR4 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway.

  5. PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall

  6. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (zeige LDLR Proteine).

  7. Use Crispr-Cas (zeige CTNND1 Proteine) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  8. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  9. These observations suggest positive feedback interplay between SMC (zeige DYM Proteine)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  10. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (zeige APOE Proteine)(-/-) mice.

PCSK9 Protein Überblick

Protein Überblick

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Genbezeichner und Symbole assoziert mit PCSK9

  • proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L)
  • proprotein convertase subtilisin/kexin type 9 (pcsk9)
  • proprotein convertase subtilisin/kexin type 9 (PCSK9)
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9)
  • AI415265 Protein
  • AI747682 Protein
  • FH3 Protein
  • HCHOLA3 Protein
  • LDLCQ1 Protein
  • NARC-1 Protein
  • Narc1 Protein
  • PC9 Protein

Bezeichner auf Proteinebene für PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPEZIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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