PCSK9 Protein (AA 31-692) (His tag)
-
- Target Alle PCSK9 Proteine anzeigen
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 31-692
-
Spezies
- Cynomolgus
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PCSK9 Protein ist gelabelt mit His tag.
- Sequenz
- AA 31-692
- Produktmerkmale
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 20 kDa and 65 kDa under reducing (R) condition (SDS-PAGE).
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product PCSK9 Protein
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
-
- Target
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- Andere Bezeichnung
- PCSK9 (PCSK9 Produkte)
- Synonyme
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- Hintergrund
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
- Molekulargewicht
- 13.9 kDa and 59.3 kDa
- UniProt
- G7NVZ1
-