PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 31-691
Spezies
Ratte
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses PCSK9 Protein ist gelabelt mit His tag.
Sequenz
AA 31-691
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 22 and 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
PCSK9
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
PCSK9
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE
Active
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
50 mM Tris, 150 mM NaCl, pH 7.5
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Target
PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).