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PCSK9 Protein (AA 31-691) (His tag)

PCSK9 Spezies: Ratte Wirt: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
Produktnummer ABIN2181592
  • Target Alle PCSK9 Proteine anzeigen
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 31-691
    Spezies
    • 20
    • 11
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Ratte
    Quelle
    • 25
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses PCSK9 Protein ist gelabelt mit His tag.
    Sequenz
    AA 31-691
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 22 and 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by reduced SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PCSK9 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 150 mM NaCl, pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Target
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Andere Bezeichnung
    PCSK9 (PCSK9 Produkte)
    Synonyme
    FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
    Hintergrund
    Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
    Molekulargewicht
    13.9 kDa and 59.3 kDa
    NCBI Accession
    NP_954862
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