PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 31-691
Spezies
Ratte
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses PCSK9 Protein ist gelabelt mit His tag.
Sequenz
AA 31-691
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73.2 kDa. The protein migrates as 22 and 66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Crystallography grade
PCSK9
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA, Crys
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
50 mM Tris, 150 mM NaCl, pH 7.5
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Target
PCSK9
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
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Hintergrund
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).