anti-Ratte (Rattus) TICAM1 Antikörper für Immunohistochemistry

Recommended TICAM1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antikörper
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
Reaktivität
Maus, Ratte (Rattus), Human
80
29
13
4
4
1
1
Wirt
Kaninchen
73
8
8
Klonalität
Polyklonal
Konjugat
Dieser TICAM1 Antikörper ist unkonjugiert
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
82
29
18
17
13
8
8
4
4
2
1
1
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Bilder

Produktnummer ABIN3021572
$ 393.25
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
16.014114 ABIN6265566 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10.014114 ABIN5965992 IHC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2879671 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN6292306 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2902677 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1994949 IHC WB Rabbit IgG Anmelden zum Anzeigen 0

General

Antigen Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antikörper
Reaktivität Maus, Ratte (Rattus), Human
(80), (29), (13), (4), (4), (1), (1)
Wirt Kaninchen
(73), (8), (8)
Klonalität
Polyklonal
Konjugat Dieser TICAM1 Antikörper ist unkonjugiert
(1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(82), (29), (18), (17), (13), (8), (8), (4), (4), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TICAM1 Antikörper

Target Details TICAM1 Anwendungsinformationen Handhabung Bilder
Reinigung Affinity purification
Immunogen Recombinant protein of human TICAM1
Isotyp IgG
Plasmids, Primers & others

Target Details TICAM1

Produktdetails anti-TICAM1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung TICAM1 (TICAM1 Antibody Abstract)
Hintergrund Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production. Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively. TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation. In addition, TRIF can trigger signaling of that lead to the induction of apoptosis.
Synonyms: TRIF, PRVTIRB, TICAM-1
Gen-ID 148022
UniProt Q8IUC6
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Handhabung Bilder zurück nach oben
Applikations-hinweise Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze / thaw cycles
Lagerung -20 °C/-80 °C

Bilder

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN3021572) anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN3021572) Western blot analysis of extracts of various cell lines, using TICAM1 antibody.