TICAM1 Antikörper (Toll-Like Receptor Adaptor Molecule 1) (AA 115-143)

Details for Product anti-TICAM1 Antibody No. ABIN1881885, Anbieter: Anmelden zum Anzeigen
Antigen
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
Epitop
AA 115-143, N-Term
26
5
4
4
3
3
2
2
2
2
2
2
2
1
1
1
Reaktivität
Human, Maus
80
30
15
5
4
2
2
Wirt
Kaninchen
73
8
8
Klonalität
Polyklonal
Konjugat
Dieser TICAM1 Antikörper ist unkonjugiert
1
Applikation
Western Blotting (WB)
82
30
18
17
13
8
8
4
4
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Plasmids, Primers & others Plasmide, Primers & weitere TICAM1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung TICAM1 (TICAM1 Antibody Abstract)
Hintergrund Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Synonyms: TICAM1,PRVTIRB, TRIF, TIR domain-containing adapter molecule 1, TIR domain-containing adapter molecule 1, Proline-rich, vinculin and TIR domain-containing protein B, TIR domain-containing adapter molecule 1, Putative NF-kappa-B-activating protein 502H, TIR domain-containing adapter molecule 1, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
NCBI Accession NP_891549
UniProt Q8IUC6
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Applikations-hinweise WB: 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Bilder des Herstellers
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 115-143), (N-Term) antibody (ABIN1881885) TICAM1 Antibody (N-term) (ABIN1881885) western blot analysis in Ramos cell line and m...
Produkt verwendet in: Nakajima, Ohtani, Satta, Uno, Akari, Ishida, Kimura: "Natural selection in the TLR-related genes in the course of primate evolution." in: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, 2008 (PubMed).

Bin, Xu, Shu: "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 24526-32, 2003 (PubMed).

Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, 2003 (PubMed).

Matsuda, Suzuki, Honda, Muramatsu, Matsuzaki, Nagano, Doi, Shimotohno, Harada, Nishida, Hayashi, Sugano: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." in: Oncogene, Vol. 22, Issue 21, pp. 3307-18, 2003 (PubMed).

Yamamoto, Sato, Mori, Hoshino, Takeuchi, Takeda, Akira: "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 6668-72, 2002 (PubMed).

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