TICAM1 Antikörper (C-Term)

Produktnummer ABIN3029185

Produktdetails anti-TICAM1 Antikörper

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the TRIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Andere Bezeichnung: TRIF (TICAM1 Produkte)

Synonyme: IIAE6 antikoerper, MyD88-3 antikoerper, PRVTIRB antikoerper, TICAM-1 antikoerper, TRIF antikoerper, AW046014 antikoerper, AW547018 antikoerper, trif antikoerper, toll like receptor adaptor molecule 1 antikoerper, toll-like receptor adaptor molecule 1 antikoerper, TICAM1 antikoerper, Ticam1 antikoerper, ticam1 antikoerper

Hintergrund: TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with < a href=../search_result.php?search_txt=TLR3>TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either < a href=../search_result.php?search_txt=nfkb>NFKB, < a href=../search_result.php?search_txt=ap1>AP1, or < a href=../search_result.php?search_txt=irf3>IRF3. TRIF activation of NFKB was found to occur predominantly through < a href=../search_result.php?search_txt=irak1>IRAK1 rather than < a href=../search_result.php?search_txt=irak2>IRAK2. siRNA blockage of the protein reduced IFNB production in response to dsRNA.

UniProt: Q8IUC6

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades