Oncostatin M Protein (OSM) (AA 27-221) (His tag)

Produktnummer ABIN7504490

Produktdetails

Target: Oncostatin M (OSM)

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-221

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Oncostatin M Protein ist gelabelt mit His tag.

Verwendungszweck: Cynomolgus Oncostatin M/OSM Protein

Sequenz: Ala27-Arg221

Produktmerkmale: Recombinant Cynomolgus Oncostatin M/OSM Protein is expressed from HEK293 with His tag at the C-terminus.It contains Ala27-Arg221.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Oncostatin M (OSM)

Andere Bezeichnung: Oncostatin M (OSM Produkte)

Synonyme: OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein

Hintergrund: OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

Molekulargewicht: 23.31 kDa. Due to glycosylation, the protein migrates to 27-50 kDa based on Tris-Bis PAGE result.

NCBI Accession: XP_045219762

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion