IFNA Protein (AA 27-243) (His tag)

Produktnummer ABIN7274844

Produktdetails

Target: IFNA (Interferon alpha (IFNA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-243

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IFNA Protein ist gelabelt mit His tag.

Verwendungszweck: Human IFN alpha/beta R2 Protein

Sequenz: Ile27-Lys243

Produktmerkmale: Recombinant Human IFN alpha/beta R2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile27-Lys243.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 11.90 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: IFNA (Interferon alpha (IFNA))

Andere Bezeichnung: IFN alpha (IFNA Produkte)

Synonyme: IFN-alphaO Protein, IFN-ALPHA-1 Protein, IFN1@ Protein, Ifa Protein, Ifa8 Protein, interferon alpha 16 Protein, interferon, alpha 1 Protein, interferon alpha Protein, interferon-alpha Protein, IFNA16 Protein, IFNA1 Protein, Ifna Protein, IFNA Protein

Hintergrund: Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.

Molekulargewicht: 25.8 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

Pathways: JAK-STAT Signalweg, TLR Signalweg, Hepatitis C, Inflammasome