PTPN11 Protein (His tag)

Produktnummer ABIN7197591

Produktdetails

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PTPN11 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse SHP2/PTPN11 Protein (His Tag)(Active)

Sequenz: Met1-Arg593

Produktmerkmale: A DNA sequence encoding the mouse PTPN11 (P35235-2) (Met1-Arg593) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 90 % as determined by SDS-PAGE

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006).The specific activity is > 1 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Andere Bezeichnung: SHP2/PTPN11 (PTPN11 Produkte)

Synonyme: BPTP3 Protein, CFC Protein, NS1 Protein, PTP-1D Protein, PTP2C Protein, SH-PTP2 Protein, SH-PTP3 Protein, SHP2 Protein, 2700084A17Rik Protein, AW536184 Protein, PTP1D Protein, SAP-2 Protein, SHP-2 Protein, Shp2 Protein, Syp Protein, SYP Protein, bptp3 Protein, cfc Protein, ns1 Protein, ptp-2 Protein, ptp2c Protein, ptpn11 Protein, ptpn11-a Protein, ptpn11-b Protein, shp-2 Protein, shp2 Protein, fa14b09 Protein, wu:fa14b09 Protein, wu:fi24f03 Protein, zgc:55388 Protein, zgc:63553 Protein, protein tyrosine phosphatase, non-receptor type 11 Protein, protein tyrosine phosphatase, non-receptor type 11 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 11, a Protein, protein tyrosine phosphatase, non-receptor type 11, b Protein, PTPN11 Protein, Ptpn11 Protein, ptpn11.S Protein, ptpn11a Protein, ptpn11b Protein

Substanzklasse: Viral Protein

Hintergrund:

Background: SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. It also dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

Synonym: 2700084A17Rik,AW536184,PTP1D,PTP2C,SAP-2,SH-PTP2,SH-PTP3,SHP-2,Shp2,Syp

Molekulargewicht: 69.5 kDa

Pathways: JAK-STAT Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effekt