IL36A/IL1F6 Protein (His tag)

Produktnummer ABIN7196299

Produktdetails

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IL36A/IL1F6 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human IL1F6/IL36A Protein (His Tag)

Sequenz: Lys 6-Phe158

Produktmerkmale: A DNA sequence encoding the mature form of human IL1F6 (Q9UHA7) (Lys 6-Phe158) was expressed with a polyhistide tag at the N-terminus.

Reinheit: > 99 % as determined by reducing SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))

Andere Bezeichnung: IL1F6/IL36A (IL1F6 Produkte)

Synonyme: Il1f6 Protein, Fil1 Protein, IL-1H1 Protein, IL1RP2 Protein, Il1f9 Protein, Il36a Protein, FIL1 Protein, FIL1(EPSILON) Protein, FIL1E Protein, IL-1F6 Protein, IL1(EPSILON) Protein, IL1F6 Protein, interleukin 36, alpha Protein, interleukin 1 family, member 6 (epsilon) Protein, interleukin 1 family, member 6 Protein, interleukin 36 alpha Protein, Il36a Protein, IL1F6 Protein, IL36A Protein, Il1f6 Protein

Hintergrund:

Background: Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Synonym: Interleukin-36 Alpha, FIL1 Epsilon, Interleukin-1 Epsilon, IL-1 Epsilon, Interleukin-1 Family Member 6, IL-1F6, IL36A, FIL1E, IL1E, IL1F6

Molekulargewicht: 19.2 kDa

UniProt: Q9UHA7

Pathways: Cancer Immune Checkpoints