CD36 Protein (CD36) (His tag,AVI tag)

Produktnummer ABIN7320864

Produktdetails

Target: CD36

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses CD36 Protein ist gelabelt mit His tag,AVI tag.

Verwendungszweck: Recombinant Mouse CD36/SCARB3 Protein (AVI & His Tag)

Sequenz: Gly30-Lys439

Produktmerkmale: Biotinylated Recombinant Mouse Platelet Glycoprotein 4 is produced by our Mammalian expressionsystem and the target gene encoding Gly30-Lys439 is expressed with a Avi-6His tag at the C-terminus.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD36

Andere Bezeichnung: CD36/SCARB3 (CD36 Produkte)

Synonyme: BDPLT10 Protein, CHDS7 Protein, FAT Protein, GP3B Protein, GP4 Protein, GPIV Protein, PASIV Protein, SCARB3 Protein, Fat Protein, Scarb3 Protein, GPIIIB Protein, PAS-4 Protein, zgc:92513 Protein, CD36 molecule Protein, CD36 molecule (thrombospondin receptor) Protein, CD36 Protein, Cd36 Protein, cd36 Protein

Hintergrund:

Background: Platelet Glycoprotein 4(CD36) is belongs to the class B scavenger receptor family. The molecule CD36 is synthesized as a 472 amino acid (aa) protein that contains a 6 aa N-terminal cytoplasmic domain, a 22 aa N-terminal transmembrane segment, a 420 aa extracellular ""loop"", a 22 aa C-terminal transmembrane segment, and a 9 aa C-terminal cytoplasmic tail. Both cytoplasmic tails are palmitoylated, with the C-terminal tail involved in oxidized LDL binding. With respect to the extracellular loop, the N-terminal region is believed to bind both thrombospondin-1 and Plasmodium-infected erythrocytes. Other ligands for CD36 include long-chain fatty acids, collagen, phospholipids and apoptotic cells. Cells known to express CD36 include capillary endothelium, adipocytes, skeletal muscle cells, intestinal epithelium, smooth muscle cells and hematopoietic cells such as RBC's, platelets and monocytes. On the surface of cells, CD36 is suggested to exist as a dimer in response to ligation (7). CD36 is reported to regulate fatty uptake, act as an angiogenic with TSP-1, and participate in the clearance of apoptotic phagocytes.

Synonym: Glycoprotein IIIb, GPIIIB, PAS IV, PAS-4, Platelet glycoprotein IV, GPIV, CD36

Molekulargewicht: 49 kDa

UniProt: Q08857

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine