CD36 Protein (CD36) (AA 30-439) (His tag)
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- Target Alle CD36 Proteine anzeigen
- CD36
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 30-439
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses CD36 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Mouse CD36 / SR-B3 Protein, His Tag
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD36 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Lagerung
- -20 °C
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- Target
- CD36
- Andere Bezeichnung
- CD36 (CD36 Produkte)
- Synonyme
- BDPLT10 Protein, CHDS7 Protein, FAT Protein, GP3B Protein, GP4 Protein, GPIV Protein, PASIV Protein, SCARB3 Protein, Fat Protein, Scarb3 Protein, GPIIIB Protein, PAS-4 Protein, zgc:92513 Protein, CD36 molecule Protein, CD36 molecule (thrombospondin receptor) Protein, CD36 Protein, Cd36 Protein, cd36 Protein
- Hintergrund
- CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
- Molekulargewicht
- 48.3 kDa
- NCBI Accession
- NP_031669
- Pathways
- TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine
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