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Human Polyclonal MECP2 Primary Antibody für ICC, IF - ABIN269308
LaSalle, Goldstine, Balmer, Greco: Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. in Human molecular genetics 2001
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Human Monoclonal MECP2 Primary Antibody für ChIP, ICC - ABIN2668836
Ganguly, Chen, Shin, Devaskar: Prenatal caloric restriction enhances DNA methylation and MeCP2 recruitment with reduced murine placental glucose transporter isoform 3 expression. in The Journal of nutritional biochemistry 2014
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Cow (Bovine) Polyclonal MECP2 Primary Antibody für WB - ABIN2781332
Robertson, Hall, Jacoby, Ellaway, de Klerk, Leonard: The association between behavior and genotype in Rett syndrome using the Australian Rett Syndrome Database. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006
Show all 2 Pubmed References
Human Monoclonal MECP2 Primary Antibody für ChIP, ICC - ABIN2668837
Jost, Rottach, Milden, Bertulat, Becker, Wolf, Sandoval, Petazzi, Huertas, Esteller, Kremmer, Leonhardt, Cardoso: Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies. in PLoS ONE 2011
Human Polyclonal MECP2 Primary Antibody für ICC, IF - ABIN252309
Ruddock-DCruz, Xue, Wilson, Heffernan, Prashadkumar, Cooney, Sanchez-Partida, French, Holland: Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. in Molecular reproduction and development 2007
Human Polyclonal MECP2 Primary Antibody für ICC, IF - ABIN4333391
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
The authors find that astrocyte stimulation in wild-type mice increases excitatory synaptic activity that is absent in male mice lacking MeCP2 globally. The defect is dependent upon MeCP2 expression status in the astrocytes and not in the neurons.
These dysregulated genes provide a better understanding of the underlying mechanisms of the effect of MeCP2 on heart failure and might be used as targets and prognostic markers of heart failure.
MECP2 gene rs17435 polymorphism was associated with juvenile idiopathic arthritis predisposition. Considering the involvement of genetic polymorphisms of MECP2 gene in susceptibility to adult-onset RA, this gene might basically play a role in the initiation of arthritis during early stages of life.
MECP2 is not associated with disease susceptibility in JSLE patients, implying the involvement of different susceptibility genes in the pathogenesis of Systemic Lupus Erythematosus and Juvenile-Onset Systemic Lupus Erythematosus
We report on two dizygotic twins with an MECP2-related psychiatric disorder without intellectual disability. We found a c.491G>T [ChrX:153296788C>A (Hg19)] transversion in exon 4 of the MECP2 gene in both patients. It was predicted to change a highly conserved serine to isoleucine, p.(Ser164Ile)
Males with Rett syndrome and missense mutations in MECP2 display a phenotype that correlates with impaired function of MECP2.
Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction
This study suggests that methylation of Wnt (zeige WNT2 Antikörper) pathway genes, in addition to known CpG island methylator phenotype markers, may help predict treatment outcome and survival in patients with CRC (zeige CALR Antikörper)[colorectal cancer.
Results show that highly expressed phospho-MeCP2-S421 and its association with VEGF in proliferative diabetic retinopathy (PDR) membranes suggests that phospho-MeCP2-S421 might involve in the pathogenesis of PDR.
MeCP2 behaves similarly to histone H1 (zeige H1F0 Antikörper) and HMGD1 in creating a higher-order chromatin structure, which is susceptible to chromatin remodeling by ISWI (zeige SMARCA1 Antikörper).
Authors used a well-characterized motor suppressive effect of nAChR agonists on mouse open field locomotor behavior to probe effects of MeCP2 mutation on cholinergic transmission.
Protein levels of p-MeCP2 were increased in high glucose or TGF-beta (zeige TGFB1 Antikörper)-treated mouse glomerular mesangial cells. The SIAH1 (zeige SIAH1 Antikörper)/HIPK2 (zeige HIPK2 Antikörper)/MeCP2 axis played a novel role for in suppressing miR (zeige MLXIP Antikörper)-25 processing and thereby upregulating NOX4 (zeige NOX4 Antikörper) in early diabetic nephropathy.
Study shows defective GABAergic neurotransmission in the nucleus tractus solitarius (NTS) methyl-CpG binding protein 2-null mice, a model of Rett syndrome. In addition the study found an increase in the delta subunit of the GABAA-receptors in the NTS in Mecp2-null mice, consistent with increased extrasynaptic receptors.
disruption of AT-hook 1 domain in MeCP2 caused behavioral abnormality in mice, which suggests that AT-hook 1 is a critical region for the function of MeCP2 protein
temporal regulation of S164 phosphorylation controls the ability of MeCP2 to regulate neuronal morphology.
Two putative modulators of MeCP2, HIPK2 (homeodomain-interacting protein kinase 2 (zeige HIPK2 Antikörper)) and PP2A (zeige PPP2R2B Antikörper) (protein phosphatase 2A), were validated as stabilizers of MeCP2 in vivo.
BMP/TGF-beta signaling pathway regulates X-inactive specific transcript (XIST), and whose down-regulation reactivated the methyl CpG binding protein 2 (MeCP2) reporter on the inactive X chromosome (Xi).
These subtle changes in myelinated peripheral nerve fibers in heterozygous Mecp2 knockout mice could potentially explain some RTT phenotypes.
MeCP2 tunes gene expression in neurons by binding within the transcribed regions of genes to impede the elongation of RNA polymerase
The pathological induction of MeCP2E1 isoform contributes to disruption of normal homeostatic signaling equilibrium network that exists between cytokines, neurotrophins and chemokines that regulate the myelin repair process by repressing BDNF (zeige BDNF Antikörper). Elevated ratio of MeCP2E1/MeCP2E2 may be a useful diagnostic marker that clinicians can utilize to determine the degree of neurological disability with associated myelin damage
Mecp2 is required for tnfa (zeige TNF Antikörper) expression during zebrafish development and inflammation.
The results of this study imply that Mecp2 is an important functional regulator of bdnf (zeige BDNF Antikörper) gene expression during neural circuit formation in zebrafish embryo
a proteomic analysis to examine protein expression changes in mecp2-null vs. wild-type larvae and adult zebrafish
A mecp2-null allele mutation zebrafish model is developed and the animals are viable and fertile.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
, methyl-CpG-binding protein 2
, meCP-2 protein
, methyl-CpG-binding protein MeCP2