MECP2 Antikörper (pSer423)

Produktnummer ABIN650833

Produktdetails anti-MECP2 Antikörper

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Bindungsspezifität: pSer423

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MeCP2.

Klon: RB29261

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500. WB: 1:500. WB: 1:500. IHC-P-Leica: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-MECP2 Antikörper (ABIN650833)

Qiu, Sylwestrak, Lieberman, Zhang, Liu, Ghosh: "The Rett syndrome protein MeCP2 regulates synaptic scaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 3, pp. 989-94, (2012) (PubMed).

Stansfield, Pilsner, Lu, Wright, Guilarte: "Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 127, Issue 1, pp. 277-95, (2012) (PubMed).

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2 (MECP2 Produkte)

Synonyme: AUTSX3 antikoerper, MRX16 antikoerper, MRX79 antikoerper, MRXS13 antikoerper, MRXSL antikoerper, PPMX antikoerper, RS antikoerper, RTS antikoerper, RTT antikoerper, 1500041B07Rik antikoerper, BB130002 antikoerper, D630021H01Rik antikoerper, Mbd5 antikoerper, WBP10 antikoerper, wu:fk96a04 antikoerper, zgc:111857 antikoerper, methyl-CpG binding protein 2 antikoerper, methyl CpG binding protein 2 antikoerper, methyl-CpG binding protein 2 S homeolog antikoerper, MECP2 antikoerper, Mecp2 antikoerper, mecp2 antikoerper, mecp2.S antikoerper

Hintergrund: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Molekulargewicht: 52441

Gen-ID: 4204

NCBI Accession: NP_001104262, NP_004983

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane