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Alzheimer’s disease

Alzheimer's disease is the most common form of dementia. About 50 million people worldwide suffer from Alzheimer's disease(1). A further increase in the number of cases is expected by 2050, partly due to the fundamental rise in life expectancy. The clinical picture is characterised by a progressive loss of cognitive abilities. The neurological hallmarks are the presence of neuritic plaques and neurofibrillary tangles of proteins in brain tissue. Ultimately, the disease leads to death.

Here you will find a list of important antibodies, reagents, kits, and other tools you need for your research in the field of neurodegenerative diseases and especially Alzheimer's, as well as some more additional resources on the topic.

Important targets related to Alzheimer's Disease

The following targets are directly related to research on Alzheimer's disease. Search Antibodies, Kits, Reagents and other products.

Amyloid beta and Tau Protein

Amyloid beta and tau protein are two of the major players in Alzheimer's Disease research. Below you will find a handpicked selection of antibodies with human and mouse reactivity. Click on a link to get more details.

Amyloid beta Antibodies: Reactivity in Human and Mouse

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman, Mouse
KlonalitätMonoclonal
ApplikationIHC (p), WB
Kat. Nr.ABIN1105360
Menge0.1 mg
ReaktivitätHuman
KlonalitätMonoclonal
ApplikationIHC, ELISA
Kat. Nr.ABIN459388
Menge50 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationELISA, IF, WB
Kat. Nr.ABIN5508784
Menge100 μg
ReaktivitätHuman, Mouse
KlonalitätPolyclonal
ApplikationIHC, ELISA, WB
Kat. Nr.ABIN95037
Menge100 μg

See all Amyloid beta Antibodies

Tau Protein Antibodies: Reactivity in Human and Mouse

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationIF, IHC, WB
Kat. Nr.ABIN2443721
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätMonoclonal
ApplikationICC, IP, IHC, WB
Kat. Nr.ABIN1742567
Menge100 μg
ReaktivitätHuman, Mouse, Rat
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN6711926
Menge100 μL

See all Tau Protein Antibodies

Beta- / Gamma-Secretase Kits

Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's disease. Currenty, the mechanisms of Abeta generation and Abeta prevention are subject of intensive research. Amyloid precursor protein (APP), as well as beta- and gamma-secretases are the principal players involved in Abeta production, while alpha-secretase cleavage on APP prevents Abeta deposition. Inhibitors or modulators that target beta- and gamma-secretases as well as alpha-secretase activators are promising candidates for treatment of Alzheimer's disease.(3) We currently offer three kits for secretase detection.

Produkt
Reaktivität
Detection Method
Kat. Nr.
Menge
ReaktivitätMammalian
Detection MethodFluorometric
Kat. Nr.ABIN411640
Menge100 tests
ReaktivitätHuman
Detection MethodColorimetric
(Pre-coated)
Kat. Nr.ABIN577496
Menge96 tests
ReaktivitätMouse
Detection MethodColorimetric
(Pre-coated)
Kat. Nr.ABIN367383
Menge96 tests

Tools for Tau Protein Phosphorylation

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and some frontotemporal dementias. Increasing evidence suggests that the presence of these end-stage neurofibrillary lesions do not cause neuronal loss, but rather that alterations to soluble tau proteins induce neurodegeneration.(2)

Produkt
Reaktivität
Bindungsspezifität
Kat. Nr.
Menge
ReaktivitätHuman
BindungsspezifitätpSer202
Kat. Nr.ABIN1883485
Menge50 μg

See all Tau Protein Antibodies

Lysates for AD Research

We offer a variety of lysates for use in Western Blotting for Alzheimer's Disease research: See all products

References

(1) Alzheimer’s Research UK. Dementia Statistics Hub - Global Prevalence. Internet: www.dementiastatistics.org/statistics/global-prevalence/

(2) Noble W, Hanger DP, Miller CC, Lovestone S. The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol. 2013 Jul 1;4:83. doi: 10.3389/fneur.2013.00083. PMID: 23847585; PMCID: PMC3696910.

(3) Epis, Marcello, Gardoni, Di Luca. Alpha, beta-and gamma-secretases in alzheimer's disease, Frontiers in Bioscience S4, 1126-1150 , January 1, 2012